glrba glycine receptor, beta a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: glrbaprovided by ZNC
Official Full Name: glycine receptor, beta aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010410-2
See related: Ensembl:ENSDARG00000052782 AllianceGenome:ZFIN:ZDB-GENE-010410-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: [b]Z; glrb; glrb1; fj42f03; wu:fj42f03
Summary: Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chloride transmembrane transport; glycinergic synaptic transmission; and regulation of membrane potential. Predicted to act upstream of or within chloride transport and monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in hindbrain and spinal cord. Human ortholog(s) of this gene implicated in hyperekplexia 2. Orthologous to human GLRB (glycine receptor beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (21423005..21491666, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (20730068..20790945, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly glycine-gated chloride channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glycinergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glycine receptor, beta a

Names: GlyR [b]Z; etID17582.1; glyR beta; gylcine receptor, beta a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131781.1 → NP_571856.1 glycine receptor, beta a precursor

See identical proteins and their annotated locations for NP_571856.1

Status: VALIDATED

Source sequence(s)

BX284619, CU075714

UniProtKB/TrEMBL

A0A8M1PCY0, A0A8M6YXY6, E9QB20, Q9DES8

Related

ENSDARP00000093565.5, ENSDART00000102790.6

Conserved Domains (3) summary

TIGR00860
Location:52 → 497

LIC; Cation transporter family protein

pfam02931
Location:59 → 265

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:272 → 494

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

21423005..21491666 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068220872.1 → XP_068076973.1 glycine receptor, beta a isoform X2

UniProtKB/TrEMBL

A0A8M6YXY6
XM_068220871.1 → XP_068076972.1 glycine receptor, beta a isoform X1

UniProtKB/TrEMBL

A0A8M6YXY6
XM_068220873.1 → XP_068076974.1 glycine receptor, beta a isoform X3

UniProtKB/TrEMBL

A0A8M6YXY6