tgfbi transforming growth factor, beta-induced [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tgfbiprovided by ZNC
Official Full Name: transforming growth factor, beta-inducedprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-73
See related: Ensembl:ENSDARG00000071586 AllianceGenome:ZFIN:ZDB-GENE-030131-73
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: BIGH3; big-h3; hm:zeh0933; wu:fa13f05; zgc:110495
Summary: Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within cellular response to xenobiotic stimulus and muscle cell development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including head mesenchyme; liver; neural crest cell; paraxial mesoderm; and splanchnocranium. Human ortholog(s) of this gene implicated in corneal dystrophy (multiple). Orthologous to human TGFBI (transforming growth factor beta induced). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (26511041..26536497, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (26212936..26238392, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mimicking TGFBI Hot-Spot Mutation Did Not Result in Any Deposit Formation in the Zebrafish Cornea.
Title: Mimicking TGFBI Hot-Spot Mutation Did Not Result in Any Deposit Formation in the Zebrafish Cornea.
This study shows that upregulation of bigh3 and bambia mRNA correlated with the process of fin regeneration and regulation of TGF-b signaling, suggesting a new role for these proteins.
Title: Bigh3 is upregulated in regenerating zebrafish fin.
Results describe the distribution of TGFBI in the developing skeletal muscle of zebrafish embryos, and use antisense morpholino oligonucleotides to investigate the function of the endogenous protein.
Title: The extracellular matrix protein TGFBI promotes myofibril bundling and muscle fibre growth in the zebrafish embryo.

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General gene information

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Markers

AA605896 (e-PCR)
- UniSTS:206878

fa13f05.s1 (e-PCR)
- UniSTS:202365

AI353749 (e-PCR)
- UniSTS:206751

fd59d03.y1 (e-PCR)
- UniSTS:195756

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transforming growth factor-beta-induced protein ig-h3

Names: etID38199.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.