dnm2b dynamin 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dnm2bprovided by ZNC
Official Full Name: dynamin 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2371
See related: AllianceGenome:ZFIN:ZDB-GENE-040426-2371
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dnm2; dnm2l; zgc:77233
Summary: Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within several processes, including glomerular filtration; muscle cell development; and podocyte development. Predicted to be located in cytoplasm and microtubule. Is expressed in brain; heart; liver; muscle; and spinal cord. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (58853360..58880378, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (58135604..58183375, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003334086.1 (263..1248, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our findings suggest that dnm2 and dnm2-like are orthologs to human DNM2, and that they are required for normal zebrafish development.
Title: Two dynamin-2 genes are required for normal zebrafish development.

Submit: New GeneRIF Correction

General gene information

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Markers

G41716 (e-PCR)
- UniSTS:25697

fj03a06.x1 (e-PCR)
- UniSTS:198307

G41094 (e-PCR)
- UniSTS:68310

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within podocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dynamin-2

Names: dynamin2-like

NP_998407.1

EC 3.6.5.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213242.1 → NP_998407.1 dynamin-2

See identical proteins and their annotated locations for NP_998407.1

Status: PROVISIONAL

Source sequence(s)

BC065325

UniProtKB/TrEMBL

Q6P122

Conserved Domains (6) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

COG0699
Location:79 → 732

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:514 → 624

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:217 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:645 → 733

GED; Dynamin GTPase effector domain

cl23807
Location:745 → 800

WWbp; WW-domain ligand protein