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    arpc1b actin related protein 2/3 complex, subunit 1B [ Danio rerio (zebrafish) ]

    Gene ID: 335474, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arpc1bprovided by ZNC
    Official Full Name
    actin related protein 2/3 complex, subunit 1Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7414
    See related
    Ensembl:ENSDARG00000027063 AllianceGenome:ZFIN:ZDB-GENE-030131-7414
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb871; arpc1a; fj15h02; zgc:64056; wu:fj08e12; wu:fj15h02
    Summary
    Predicted to enable actin filament binding activity. Acts upstream of or within T cell differentiation and thrombocyte differentiation. Predicted to be located in actin cytoskeleton; cytoplasm; and nucleus. Predicted to be part of Arp2/3 protein complex. Is expressed in blood; blood island; pectoral fin musculature; pharyngeal arch 3-7 skeleton; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; and myelodysplastic syndrome. Orthologous to human ARPC1B (actin related protein 2/3 complex subunit 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See arpc1b in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (40809048..40820479)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (40667190..40678621)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490719 Neighboring gene actin related protein 2/3 complex, subunit 1A Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene monocyte to macrophage differentiation-associated 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in ARPC1B. Somech R, et al. J Immunol, 2017 Dec 15. PMID 29127144, Free PMC Article
    2. Wnt signaling inhibition by monensin results in a period of Hippo pathway activation during intestinal adaptation in zebrafish. Isani MA, et al. Am J Physiol Gastrointest Liver Physiol, 2019 Jun 1. PMID 30896968
    3. Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo. Jerison ER, et al. Elife, 2020 May 19. PMID 32427565, Free PMC Article
    4. A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. Le X, et al. Development, 2013 Jun. PMID 23615277, Free PMC Article
    5. Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo. Oosterhof N, et al. Cell Rep, 2018 Jul 31. PMID 30067976

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thrombocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    actin-related protein 2/3 complex subunit 1B
    Names
    actin related protein 2/3 complex, subunit 1A, 41kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213156.1 → NP_998321.1  actin-related protein 2/3 complex subunit 1B

      See identical proteins and their annotated locations for NP_998321.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053229
      UniProtKB/TrEMBL
      B2GPS5, Q7T372
      Related
      ENSDARP00000038520.4, ENSDART00000033713.5
      Conserved Domains (3) summary
      COG2319
      Location:2 → 360
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:11 → 50
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:45 → 273
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      40809048..40820479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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