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    lcp2a lymphocyte cytosolic protein 2a [ Danio rerio (zebrafish) ]

    Gene ID: 336073, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lcp2aprovided by ZNC
    Official Full Name
    lymphocyte cytosolic protein 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-97
    See related
    Ensembl:ENSDARG00000055955 AllianceGenome:ZFIN:ZDB-GENE-041114-97
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fj47a12; zgc:101809
    Summary
    Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway and intracellular signal transduction. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human LCP2 (lymphocyte cytosolic protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lcp2a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (30306356..30347612)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (30269583..30310917)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene stem-loop binding protein 2 Neighboring gene zinc finger, matrin-type 2 Neighboring gene forkhead box I3a Neighboring gene uncharacterized LOC137488827

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo. Jerison ER, et al. Elife, 2020 May 19. PMID 32427565, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101809

    General protein information

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    Preferred Names
    lymphocyte cytosolic protein 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214717.1 → NP_999882.1  lymphocyte cytosolic protein 2a

      See identical proteins and their annotated locations for NP_999882.1

      Status: PROVISIONAL

      Source sequence(s)
      AF388204
      UniProtKB/TrEMBL
      Q8JI36
      Conserved Domains (2) summary
      cd09522
      Location:10 → 78
      SAM_SLP76; SAM domain of SLP76 subfamily
      cl15255
      Location:380 → 500
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      30306356..30347612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161289.5 → XP_005161346.1  lymphocyte cytosolic protein 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B875
      Conserved Domains (2) summary
      cd09522
      Location:10 → 78
      SAM_SLP76; SAM domain of SLP76 subfamily
      cl15255
      Location:389 → 509
      SH2; Src homology 2 (SH2) domain

    2. XM_005161291.5 → XP_005161348.1  lymphocyte cytosolic protein 2a isoform X2

      UniProtKB/TrEMBL
      A0A8M2B8A4
      Related
      ENSDARP00000059419.7, ENSDART00000059420.7
      Conserved Domains (2) summary
      cd09522
      Location:10 → 78
      SAM_SLP76; SAM domain of SLP76 subfamily
      cl15255
      Location:381 → 501
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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