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    kcnd3 potassium voltage-gated channel, Shal-related subfamily, member 3 [ Danio rerio (zebrafish) ]

    Gene ID: 327415, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kcnd3provided by ZNC
    Official Full Name
    potassium voltage-gated channel, Shal-related subfamily, member 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5626
    See related
    Ensembl:ENSDARG00000056101 AllianceGenome:ZFIN:ZDB-GENE-030131-5626
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55306; wu:fi06g01
    Summary
    Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion transmembrane transport. Predicted to be located in cell projection and membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in dendritic spine; neuronal cell body; and postsynaptic membrane. Is expressed in heart and nervous system. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kcnd3 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (28066074..28236472)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (28046738..28217333)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene CTTNBP2 N-terminal like b Neighboring gene uncharacterized LOC137490329 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 Neighboring gene RAP1A, member of RAS oncogene family a Neighboring gene inka box actin regulator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Functional and pharmacological characterization of a Shal-related K+ channel subunit in Zebrafish. Nakamura TY, et al. BMC Physiol, 2008 Feb 8. PMID 18261223, Free PMC Article
    2. Analysis and functional evaluation of the hair-cell transcriptome. McDermott BM Jr, et al. Proc Natl Acad Sci U S A, 2007 Jul 10. PMID 17606911, Free PMC Article
    3. Mog1 knockout causes cardiac hypertrophy and heart failure by downregulating tbx5-cryab-hspb2 signalling in zebrafish. Gou D, et al. Acta Physiol (Oxf), 2021 Mar. PMID 33032360
    4. Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. Yang S, et al. Int J Mol Sci, 2022 Jul 7. PMID 35886872, Free PMC Article
    5. Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Harden MV, et al. J Neurobiol, 2006 Nov. PMID 17013923

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables A-type (transient outward) potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    A-type voltage-gated potassium channel KCND3
    Names
    potassium voltage-gated channel, Shal-related family, member 3
    zShal3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199802.1 → NP_956096.1  A-type voltage-gated potassium channel KCND3

      See identical proteins and their annotated locations for NP_956096.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045304
      UniProtKB/TrEMBL
      A0A8M1PBW8, Q7ZW36
      Related
      ENSDARP00000072994.4, ENSDART00000078533.5
      Conserved Domains (6) summary
      smart00225
      Location:42 → 139
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:213 → 411
      Ion_trans; Ion transport protein
      pfam02214
      Location:42 → 131
      BTB_2; BTB/POZ domain
      pfam07885
      Location:327 → 407
      Ion_trans_2; Ion channel
      pfam11601
      Location:3 → 28
      Shal-type; Shal-type voltage-gated potassium channels
      pfam11879
      Location:443 → 544
      DUF3399; Domain of unknown function (DUF3399)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      28066074..28236472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167002.5 → XP_005167059.1  A-type voltage-gated potassium channel KCND3 isoform X1

      UniProtKB/TrEMBL
      A0A286Y962, A0A8M2BEB5
      Related
      ENSDARP00000143711.1, ENSDART00000178481.2
      Conserved Domains (6) summary
      smart00225
      Location:42 → 139
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:213 → 411
      Ion_trans; Ion transport protein
      pfam02214
      Location:42 → 131
      BTB_2; BTB/POZ domain
      pfam07885
      Location:327 → 407
      Ion_trans_2; Ion channel
      pfam11601
      Location:3 → 28
      Shal-type; Shal-type voltage-gated potassium channels
      pfam11879
      Location:443 → 556
      DUF3399; Domain of unknown function (DUF3399)

    2. XM_005167003.5 → XP_005167060.1  A-type voltage-gated potassium channel KCND3 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BF04
      Conserved Domains (6) summary
      smart00225
      Location:42 → 139
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:213 → 411
      Ion_trans; Ion transport protein
      pfam02214
      Location:42 → 131
      BTB_2; BTB/POZ domain
      pfam07885
      Location:327 → 407
      Ion_trans_2; Ion channel
      pfam11601
      Location:3 → 28
      Shal-type; Shal-type voltage-gated potassium channels
      pfam11879
      Location:443 → 555
      DUF3399; Domain of unknown function (DUF3399)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395273.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      248556..263573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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