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    arhgap42a Rho GTPase activating protein 42a [ Danio rerio (zebrafish) ]

    Gene ID: 566275, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arhgap42aprovided by ZNC
    Official Full Name
    Rho GTPase activating protein 42aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8077
    See related
    Ensembl:ENSDARG00000056619 AllianceGenome:ZFIN:ZDB-GENE-030131-8077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj51b01; arhgap42; bZ1P14.10; wu:fj51b01; si:rp71-1p14.10
    Summary
    Predicted to enable GTPase activator activity. Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm. Orthologous to human ARHGAP42 (Rho GTPase activating protein 42). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See arhgap42a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (22738939..22796064)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (22702334..22759459)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene F-box protein 40, tandem duplicate 1 Neighboring gene F-box protein 40, tandem duplicate 2 Neighboring gene transient receptor potential cation channel, subfamily C, member 6a Neighboring gene angiopoietin-like 5 Neighboring gene cilia and flagella associated protein 300

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    2. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 42
    Names
    oligophrenin-1 like
    rho-type GTPase-activating protein 42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202443.2 → NP_001189372.2  rho GTPase-activating protein 42

      Status: VALIDATED

      Source sequence(s)
      BX510940, CU695000
      UniProtKB/Swiss-Prot
      F1QUD4, Q6ZM89
      UniProtKB/TrEMBL
      A0A8M1NYY6, I3ITG1
      Related
      ENSDARP00000126225.1, ENSDART00000151342.3
      Conserved Domains (5) summary
      cd12066
      Location:826 → 880
      SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
      cd04374
      Location:369 → 567
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 376
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 369
      PH; PH domain
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      22738939..22796064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468885.2 → XP_021324560.1  rho GTPase-activating protein 42 isoform X1

      UniProtKB/Swiss-Prot
      F1QUD4, Q6ZM89
      UniProtKB/TrEMBL
      A0A8M9PU04
      Conserved Domains (5) summary
      pfam05539
      Location:674 → 757
      Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
      cd12066
      Location:846 → 900
      SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
      cd04374
      Location:389 → 587
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:267 → 396
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_068215917.1 → XP_068072018.1  rho GTPase-activating protein 42 isoform X2

      UniProtKB/Swiss-Prot
      F1QUD4, Q6ZM89

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395091.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      161655..221862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZM89.3 GenPept UniProtKB/Swiss-Prot:Q6ZM89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.