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    selenou1a selenoprotein U 1a [ Danio rerio (zebrafish) ]

    Gene ID: 323739, updated on 9-Dec-2024

    Summary

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    Official Symbol
    selenou1aprovided by ZNC
    Official Full Name
    selenoprotein U 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2459
    See related
    Ensembl:ENSDARG00000057378 AllianceGenome:ZFIN:ZDB-GENE-030131-2459
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    selu; sepu; selu1; prxl2a; fam213a; fc08d10; selenou; fam213aa; zgc:73311; wu:fb06a02; wu:fc08d10
    Summary
    The protein encoded by this gene belongs to a subfamily of FAM213A/selenoprotein U (SelU), within a peroxiredoxin-like FAM213 superfamily. SelU is unusual in that it has restricted phylogenetic distribution in vertebrates, such as in chicken and fish. Other vertebrate members of this family, including mammals, contain cysteine-containing homologues. SelU proteins contain UxxC (U for selenocysteine and C for cysteine) motif in place of the catalytic CxxC motif found in cysteine-containing homologues. The latter function as redox regulatory proteins, suggesting a similar role for SelU proteins. Like majority of selenoproteins, SelU contains a single selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. A paralog of this gene exists on chromosome 12 (GeneID:767744). [provided by RefSeq, Aug 2017]
    Orthologs
    human mouse all
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    Genomic context

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    See selenou1a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (18659346..18669575)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (18528354..18538583)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene U2 spliceosomal RNA Neighboring gene sideroflexin 3 Neighboring gene PDZ domain containing 7a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular Genetic Anatomy and Risk Profile of Hirschsprung's Disease. Tilghman JM, et al. N Engl J Med, 2019 Apr 11. PMID 30970187, Free PMC Article
    2. Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. Castellano S, et al. EMBO Rep, 2004 Jan. PMID 14710190, Free PMC Article
    3. Selenium prevents downregulation of antioxidant selenoprotein genes by methylmercury. Penglase S, et al. Free Radic Biol Med, 2014 Oct. PMID 25064324
    4. Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Doretto LB, et al. Cells, 2022 Apr 11. PMID 35455974, Free PMC Article
    5. Composition and evolution of the vertebrate and mammalian selenoproteomes. Mariotti M, et al. PLoS One, 2012. PMID 22479358, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables antioxidant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    selenoprotein U 1a
    Names
    UPF0765 protein C10orf58 homolog
    family with sequence similarity 213, member A
    family with sequence similarity 213, member Aa
    peroxiredoxin-like 2 activated in M-CSF stimulated monocytes homolog
    peroxiredoxin-like 2A
    redox-regulatory protein FAM213A
    redox-regulatory protein PAMM homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193525.1 → NP_001180454.1  selenoprotein U 1a

      See identical proteins and their annotated locations for NP_001180454.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-3 encode the same selenoprotein.
      Source sequence(s)
      BC154572, CK690434
      UniProtKB/Swiss-Prot
      Q6PBP3
      Related
      ENSDARP00000115912.1, ENSDART00000147905.3
      Conserved Domains (1) summary
      cd02970
      Location:37 → 190
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    2. NM_001354552.1 → NP_001341481.1  selenoprotein U 1a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional exon in the 5' region compared to variant 1. Variants 1-3 encode the same selenoprotein.
      Source sequence(s)
      CR932438
      UniProtKB/Swiss-Prot
      Q6PBP3
      Related
      ENSDARP00000149078.1, ENSDART00000188249.1
      Conserved Domains (1) summary
      cd02970
      Location:37 → 190
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    3. NM_001354553.1 → NP_001341482.1  selenoprotein U 1a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and an additional exon in the 5' region compared to variant 1. Variants 1-3 encode the same selenoprotein.
      Source sequence(s)
      CR932438
      UniProtKB/Swiss-Prot
      Q6PBP3
      Conserved Domains (1) summary
      cd02970
      Location:37 → 190
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      18659346..18669575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394876.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      285875..296104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_200036.1: Suppressed sequence

      Description
      NM_200036.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

    2. NR_027705.1: Suppressed sequence

      Description
      NR_027705.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PBP3.2 GenPept UniProtKB/Swiss-Prot:Q6PBP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.