pou3f1 POU class 3 homeobox 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pou3f1provided by ZNC
Official Full Name: POU class 3 homeobox 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-372
See related: Ensembl:ENSDARG00000009823 AllianceGenome:ZFIN:ZDB-GENE-980526-372
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zp50; pou50; zp-50; zp50pou; wu:fc09d06
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within brain development; cell differentiation; and regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including forebrain neural rod; hindbrain neural keel; nervous system; neural plate; and presumptive diencephalon. Orthologous to human POU3F1 (POU class 3 homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (33593116..33595985)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (33639086..33641955)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of the zebrafish Oct-6 protein is consistent with the notion that it functions as a 'competence factor' in promyelin cells to execute the myelination program.
Title: Comparison of sequence and function of the Oct-6 genes in zebrafish, chicken and mouse.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: POU domain, class 3, transcription factor 1

Names: Oct-6; POU domain gene 50; POU domain protein 50; POU domain protein ZP-50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131161.1 → NP_571236.1 POU domain, class 3, transcription factor 1

See identical proteins and their annotated locations for NP_571236.1

Status: PROVISIONAL

Source sequence(s)

X96422

UniProtKB/Swiss-Prot

A2BGW5, A7MCK3, Q6NYY2, Q90482

Related

ENSDARP00000027757.5, ENSDART00000013148.7

Conserved Domains (2) summary

smart00352
Location:187 → 261

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:282 → 335

Homeobox; Homeobox domain