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    prc1a protein regulator of cytokinesis 1a [ Danio rerio (zebrafish) ]

    Gene ID: 259194, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prc1aprovided by ZNC
    Official Full Name
    protein regulator of cytokinesis 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020801-3
    See related
    Ensembl:ENSDARG00000100918 AllianceGenome:ZFIN:ZDB-GENE-020801-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    prc1; cb212; prc1l; zgc:55982; zgc:86918
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in mitotic spindle midzone assembly. Predicted to be active in cytoplasm and mitotic spindle midzone. Is expressed in margin and proliferative region. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See prc1a in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (7435214..7459027)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (7261095..7285297)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene pseudopodium-enriched atypical kinase 1 Neighboring gene ubiquitin associated protein 1-like a Neighboring gene synaptotagmin XII Neighboring gene catalase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The midbody component Prc1-like is required for microtubule reorganization during cytokinesis and dorsal determinant segregation in the early zebrafish embryo. Nair S, et al. Development, 2023 Feb 15. PMID 36789950, Free PMC Article
    2. Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Chen J, et al. Sci China Life Sci, 2021 Dec. PMID 33751369
    3. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The midbody component Prc1-like is required for microtubule reorganization during cytokinesis and dorsal determinant segregation in the early zebrafish embryo.
      Title: The midbody component Prc1-like is required for microtubule reorganization during cytokinesis and dorsal determinant segregation in the early zebrafish embryo.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55982

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein regulator of cytokinesis 1a
    Names
    protein regulator of cytokinesis 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004494.1 → NP_001004494.1  protein regulator of cytokinesis 1a

      See identical proteins and their annotated locations for NP_001004494.1

      Status: PROVISIONAL

      Source sequence(s)
      BC075789
      UniProtKB/TrEMBL
      A0A8M1N1Z4, Q6DI02
      Related
      ENSDARP00000139061.1, ENSDART00000172567.2
      Conserved Domains (2) summary
      pfam03999
      Location:37 → 578
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      cl00278
      Location:19 → 71
      CCC1_like; CCC1-related family of proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      7435214..7459027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217306.1 → XP_068073407.1  protein regulator of cytokinesis 1a isoform X3

    2. XM_009297767.3 → XP_009296042.1  protein regulator of cytokinesis 1a isoform X4

      UniProtKB/TrEMBL
      A0A0R4IC50, A0A8M3AWC0
      Related
      ENSDARP00000130445.1, ENSDART00000163017.2
      Conserved Domains (2) summary
      pfam03999
      Location:37 → 586
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      cl00278
      Location:19 → 71
      CCC1_like; CCC1-related family of proteins

    3. XM_021470440.2 → XP_021326115.1  protein regulator of cytokinesis 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PY83
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 578
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    4. XM_068217305.1 → XP_068073406.1  protein regulator of cytokinesis 1a isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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