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    tia1l cytotoxic granule-associated RNA binding protein 1, like [ Danio rerio (zebrafish) ]

    Gene ID: 323447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tia1lprovided by ZNC
    Official Full Name
    cytotoxic granule-associated RNA binding protein 1, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2167
    See related
    Ensembl:ENSDARG00000026476 AllianceGenome:ZFIN:ZDB-GENE-030131-2167
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    TIA1; fb98f09; zgc:55893; zgc:76917; wu:fb98f09
    Summary
    Predicted to enable RNA binding activity. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tia1l in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (24510619..24517700, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (24006819..24013963, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438646 Neighboring gene uncharacterized LOC137495588 Neighboring gene microRNA mir-1306 Neighboring gene DGCR8 microprocessor complex subunit Neighboring gene tRNA methyltransferase 2 homolog A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Engineered CRISPR-Cas9 nucleases with altered PAM specificities. Kleinstiver BP, et al. Nature, 2015 Jul 23. PMID 26098369, Free PMC Article
    2. Heritable and precise zebrafish genome editing using a CRISPR-Cas system. Hwang WY, et al. PLoS One, 2013. PMID 23874735, Free PMC Article
    3. Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system. Zhang Y, et al. Nat Commun, 2017 Jul 25. PMID 28740134, Free PMC Article
    4. Efficient genome editing in zebrafish using a CRISPR-Cas system. Hwang WY, et al. Nat Biotechnol, 2013 Mar. PMID 23360964, Free PMC Article
    5. The zebrafish transcriptome during early development. Vesterlund L, et al. BMC Dev Biol, 2011 May 24. PMID 21609443, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55893

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytotoxic granule-associated RNA binding protein 1, like
    Names
    TIA1 cytotoxic granule-associated RNA binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200182.2 → NP_956476.1  cytotoxic granule-associated RNA binding protein 1, like

      See identical proteins and their annotated locations for NP_956476.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066734
      UniProtKB/TrEMBL
      F6P2U6, Q6NY54, Q7ZVM6
      Related
      ENSDARP00000018009.6, ENSDART00000003957.7
      Conserved Domains (4) summary
      cd12618
      Location:96 → 175
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12620
      Location:206 → 278
      RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
      TIGR01661
      Location:7 → 272
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:10 → 90
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      24510619..24517700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165110.5 → XP_005165167.1  cytotoxic granule-associated RNA binding protein 1, like isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCA8
      Conserved Domains (4) summary
      cd12618
      Location:96 → 175
      RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
      cd12620
      Location:206 → 278
      RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
      TIGR01661
      Location:7 → 272
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:10 → 90
      RRM_SF; RNA recognition motif (RRM) superfamily

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394576.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      206717..213788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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