acaa2 acetyl-CoA acyltransferase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: acaa2provided by ZNC
Official Full Name: acetyl-CoA acyltransferase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1996
See related: Ensembl:ENSDARG00000038881 AllianceGenome:ZFIN:ZDB-GENE-040426-1996
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb59b11; zgc:56036; wu:fb59b11
Summary: Predicted to enable acetyl-CoA C-acetyltransferase activity. Acts upstream of or within regulation of fatty acid beta-oxidation. Predicted to be active in mitochondrion. Is expressed in cardiac ventricle. Orthologous to human ACAA2 (acetyl-CoA acyltransferase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (2509625..2529878, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (2451082..2471335, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acetyl-CoA C-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of lymph vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 3-ketoacyl-CoA thiolase, mitochondrial

NP_998217.1

EC 2.3.1.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213052.1 → NP_998217.1 3-ketoacyl-CoA thiolase, mitochondrial

See identical proteins and their annotated locations for NP_998217.1

Status: PROVISIONAL

Source sequence(s)

BC045876

UniProtKB/TrEMBL

Q7ZVG1

Related

ENSDARP00000056766.5, ENSDART00000056767.6

Conserved Domains (2) summary

PRK05790
Location:5 → 396

PRK05790; putative acyltransferase; Provisional

cd00751
Location:8 → 395

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...