plp1a proteolipid protein 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: plp1aprovided by ZNC
Official Full Name: proteolipid protein 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-001202-1
See related: Ensembl:ENSDARG00000103732 AllianceGenome:ZFIN:ZDB-GENE-001202-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: DM20; plp1; DMalpha2c; wu:fc27f01; wu:fj36d03; wu:fj42d08; zgc:110499
Summary: Predicted to be a structural constituent of myelin sheath. Acts upstream of or within myelination. Predicted to be located in membrane. Predicted to be active in myelin sheath and plasma membrane. Is expressed in central nervous system; glial cell; and neural tube. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (14577655..14596699)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (14272092..14291136)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fc27f01.x1 (e-PCR)
- UniSTS:193362

fc27f01.x1 (e-PCR)
- UniSTS:193363

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural constituent of myelin sheath	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system myelination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myelination	IEP Inferred from Expression Pattern more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in myelin sheath	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proteolipid protein 1a

Names: DMalpha1; etID60288.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.