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    picalma phosphatidylinositol binding clathrin assembly protein a [ Danio rerio (zebrafish) ]

    Gene ID: 393901, updated on 9-Dec-2024

    Summary

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    Official Symbol
    picalmaprovided by ZNC
    Official Full Name
    phosphatidylinositol binding clathrin assembly protein aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-761
    See related
    Ensembl:ENSDARG00000012866 AllianceGenome:ZFIN:ZDB-GENE-040426-761
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    picalm; zgc:55615
    Summary
    Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle budding from presynaptic endocytic zone membrane. Predicted to act upstream of or within clathrin coat assembly. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and synaptic vesicle. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See picalma in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (29137999..29225165)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (29251181..29338540)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene si:ch211-103f14.3 Neighboring gene zona pellucida-like domain containing 1a Neighboring gene coiled-coil domain containing 83 Neighboring gene synaptotagmin-like 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55615

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within clathrin coat assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol binding clathrin assembly protein a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365260.1 → NP_001352189.1  phosphatidylinositol binding clathrin assembly protein a isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX005332
      UniProtKB/TrEMBL
      A0A8M9QGG0
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 286
      ANTH; ANTH domain

    2. NM_001365261.1 → NP_001352190.1  phosphatidylinositol binding clathrin assembly protein a isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX005332
      UniProtKB/TrEMBL
      A0A8M9QKL4, Q7ZVU6
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 282
      ANTH; ANTH domain

    3. NM_200927.2 → NP_957221.2  phosphatidylinositol binding clathrin assembly protein a isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX005332
      UniProtKB/TrEMBL
      A0A8M3AWT7, F1QKW9, Q7ZVU6
      Related
      ENSDARP00000021165.8, ENSDART00000025227.11
      Conserved Domains (2) summary
      pfam07651
      Location:24 → 282
      ANTH; ANTH domain
      pfam12287
      Location:337 → 436
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      29137999..29225165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479128.2 → XP_021334803.1  phosphatidylinositol binding clathrin assembly protein a isoform X8

      UniProtKB/TrEMBL
      A0A8M9Q5T8, A0A8M9QBW1
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 286
      ANTH; ANTH domain

    2. XM_009305379.4 → XP_009303654.1  phosphatidylinositol binding clathrin assembly protein a isoform X10

      UniProtKB/TrEMBL
      A0A8M3B3B4, A0A8M9QBW1
      Conserved Domains (1) summary
      pfam07651
      Location:19 → 286
      ANTH; ANTH domain

    3. XM_068223744.1 → XP_068079845.1  phosphatidylinositol binding clathrin assembly protein a isoform X11

      UniProtKB/TrEMBL
      A0A8M9QBW1

    4. XM_068223745.1 → XP_068079846.1  phosphatidylinositol binding clathrin assembly protein a isoform X12

      UniProtKB/TrEMBL
      A0A8M9QBW1

    5. XM_068223749.1 → XP_068079850.1  phosphatidylinositol binding clathrin assembly protein a isoform X25

      UniProtKB/TrEMBL
      Q7ZVU6

    6. XM_068223752.1 → XP_068079853.1  phosphatidylinositol binding clathrin assembly protein a isoform X28

      UniProtKB/TrEMBL
      Q7ZVU6

    7. XM_068223750.1 → XP_068079851.1  phosphatidylinositol binding clathrin assembly protein a isoform X26

      UniProtKB/TrEMBL
      Q7ZVU6
      Related
      ENSDARP00000144639.2, ENSDART00000178280.2

    8. XM_021479135.2 → XP_021334810.1  phosphatidylinositol binding clathrin assembly protein a isoform X19

      UniProtKB/TrEMBL
      A0A8M9QKL4, Q7ZVU6
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 282
      ANTH; ANTH domain

    9. XM_068223751.1 → XP_068079852.1  phosphatidylinositol binding clathrin assembly protein a isoform X27

      UniProtKB/TrEMBL
      Q7ZVU6

    10. XM_009305389.4 → XP_009303664.1  phosphatidylinositol binding clathrin assembly protein a isoform X29

      UniProtKB/TrEMBL
      A0A8M3AWT7, F1QKW9, Q7ZVU6
      Conserved Domains (2) summary
      pfam07651
      Location:24 → 282
      ANTH; ANTH domain
      pfam12287
      Location:337 → 436
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

    11. XM_021479138.2 → XP_021334813.1  phosphatidylinositol binding clathrin assembly protein a isoform X30

      UniProtKB/TrEMBL
      A0A8M9Q5U3, A0A8M9QBW1
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 282
      ANTH; ANTH domain

    12. XM_009305392.4 → XP_009303667.1  phosphatidylinositol binding clathrin assembly protein a isoform X31

      UniProtKB/TrEMBL
      A0A8M3B3B6, A0A8M9QBW1
      Conserved Domains (1) summary
      pfam07651
      Location:19 → 282
      ANTH; ANTH domain

    13. XM_068223753.1 → XP_068079854.1  phosphatidylinositol binding clathrin assembly protein a isoform X32

      UniProtKB/TrEMBL
      A0A8M9QGG0

    14. XM_021479123.2 → XP_021334798.1  phosphatidylinositol binding clathrin assembly protein a isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q5T5, A0A8M9QBW1
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 286
      ANTH; ANTH domain

    15. XM_009305372.4 → XP_009303647.1  phosphatidylinositol binding clathrin assembly protein a isoform X4

      UniProtKB/TrEMBL
      A0A8M3AWV7, A0A8M9QBW1
      Conserved Domains (1) summary
      pfam07651
      Location:19 → 286
      ANTH; ANTH domain

    16. XM_021479126.2 → XP_021334801.1  phosphatidylinositol binding clathrin assembly protein a isoform X3

      UniProtKB/TrEMBL
      A0A8M9QBW1, A0A8M9QGF6
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 286
      ANTH; ANTH domain

    17. XM_009305375.4 → XP_009303650.1  phosphatidylinositol binding clathrin assembly protein a isoform X6

      UniProtKB/TrEMBL
      A0A8M3AWT2, A0A8M9QBW1
      Conserved Domains (1) summary
      pfam07651
      Location:19 → 286
      ANTH; ANTH domain

    18. XM_021479127.2 → XP_021334802.1  phosphatidylinositol binding clathrin assembly protein a isoform X5

      UniProtKB/TrEMBL
      A0A8M9PTF3, A0A8M9QBW1
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 286
      ANTH; ANTH domain

    19. XM_009305376.4 → XP_009303651.1  phosphatidylinositol binding clathrin assembly protein a isoform X7

      UniProtKB/TrEMBL
      A0A8M3B694, A0A8M9QBW1
      Conserved Domains (1) summary
      pfam07651
      Location:19 → 286
      ANTH; ANTH domain

    20. XM_021479129.2 → XP_021334804.1  phosphatidylinositol binding clathrin assembly protein a isoform X9

      UniProtKB/TrEMBL
      A0A8M9QBW1, A0A8M9QBW5
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 286
      ANTH; ANTH domain

    21. XM_021479130.2 → XP_021334805.1  phosphatidylinositol binding clathrin assembly protein a isoform X13

      UniProtKB/TrEMBL
      A0A8M9QGG0, A0A8M9QKL0
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 286
      ANTH; ANTH domain

    22. XM_068223746.1 → XP_068079847.1  phosphatidylinositol binding clathrin assembly protein a isoform X14

      UniProtKB/TrEMBL
      A0A8M9QGG0

    23. XM_021479132.2 → XP_021334807.1  phosphatidylinositol binding clathrin assembly protein a isoform X15

      UniProtKB/TrEMBL
      A0A8M9PTF8, Q7ZVU6
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 286
      ANTH; ANTH domain

    24. XM_068223747.1 → XP_068079848.1  phosphatidylinositol binding clathrin assembly protein a isoform X18

      UniProtKB/TrEMBL
      Q7ZVU6

    25. XM_021479134.2 → XP_021334809.1  phosphatidylinositol binding clathrin assembly protein a isoform X17

      UniProtKB/TrEMBL
      A0A8M9QBX0, Q7ZVU6
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 286
      ANTH; ANTH domain

    26. XM_021479136.2 → XP_021334811.1  phosphatidylinositol binding clathrin assembly protein a isoform X20

      UniProtKB/TrEMBL
      A0A8M9QGG5, Q7ZVU6
      Conserved Domains (2) summary
      pfam07651
      Location:24 → 286
      ANTH; ANTH domain
      pfam12287
      Location:341 → 440
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

    27. XM_021479125.2 → XP_021334800.1  phosphatidylinositol binding clathrin assembly protein a isoform X2

      UniProtKB/TrEMBL
      A0A8M9QBW1, A0A8M9QKK5
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 282
      ANTH; ANTH domain

    28. XM_021479133.2 → XP_021334808.1  phosphatidylinositol binding clathrin assembly protein a isoform X16

      UniProtKB/TrEMBL
      A0A8M9Q5U0, Q7ZVU6
      Conserved Domains (1) summary
      pfam07651
      Location:24 → 282
      ANTH; ANTH domain

    29. XM_068223748.1 → XP_068079849.1  phosphatidylinositol binding clathrin assembly protein a isoform X21

      UniProtKB/TrEMBL
      Q7ZVU6

    30. XM_009305387.4 → XP_009303662.1  phosphatidylinositol binding clathrin assembly protein a isoform X23

      UniProtKB/TrEMBL
      A0A8M3AWV9, Q7ZVU6
      Conserved Domains (1) summary
      pfam07651
      Location:19 → 282
      ANTH; ANTH domain

    31. XM_021479137.2 → XP_021334812.1  phosphatidylinositol binding clathrin assembly protein a isoform X22

      UniProtKB/TrEMBL
      A0A8M9PTG3, Q7ZVU6
      Conserved Domains (2) summary
      pfam07651
      Location:24 → 282
      ANTH; ANTH domain
      pfam12287
      Location:337 → 436
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

    32. XM_009305388.4 → XP_009303663.1  phosphatidylinositol binding clathrin assembly protein a isoform X24

      UniProtKB/TrEMBL
      A0A8M3BD23, Q7ZVU6
      Related
      ENSDARP00000032600.7, ENSDART00000034242.9
      Conserved Domains (1) summary
      pfam07651
      Location:19 → 282
      ANTH; ANTH domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394790.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      149300..238526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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