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    smu1a SMU1 DNA replication regulator and spliceosomal factor a [ Danio rerio (zebrafish) ]

    Gene ID: 393168, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smu1aprovided by ZNC
    Official Full Name
    SMU1 DNA replication regulator and spliceosomal factor aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-916
    See related
    Ensembl:ENSDARG00000002538 AllianceGenome:ZFIN:ZDB-GENE-040426-916
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    smu1; zgc:56147
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA processing. Predicted to be located in nuclear speck. Predicted to be part of U2-type precatalytic spliceosome. Orthologous to human SMU1 (SMU1 DNA replication regulator and spliceosomal factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See smu1a in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (6228996..6245748)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (5922162..5938914)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin, like Neighboring gene si:ch73-22a13.3 Neighboring gene highly divergent homeobox Neighboring gene elongator acetyltransferase complex subunit 1 Neighboring gene TBC1 domain family, member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A beta1,4-galactosyltransferase is required for convergent extension movements in zebrafish. Machingo QJ, et al. Dev Biol, 2006 Sep 15. PMID 16904099
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56147

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WD40 repeat-containing protein SMU1
    Names
    smu-1 suppressor of mec-8 and unc-52 homolog a
    smu-1 suppressor of mec-8 and unc-52 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200199.1 → NP_956493.1  WD40 repeat-containing protein SMU1

      See identical proteins and their annotated locations for NP_956493.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045945
      UniProtKB/Swiss-Prot
      Q7ZVA0
      Related
      ENSDARP00000089117.2, ENSDART00000098346.4
      Conserved Domains (5) summary
      smart00667
      Location:5 → 38
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:40 → 90
      CTLH; C-terminal to LisH motif
      COG2319
      Location:212 → 513
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:214 → 512
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:219 → 262
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      6228996..6245748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZVA0.1 GenPept UniProtKB/Swiss-Prot:Q7ZVA0

    Gene LinkOut

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