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    mdc1 mediator of DNA damage checkpoint 1 [ Danio rerio (zebrafish) ]

    Gene ID: 569805, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mdc1provided by ZNC
    Official Full Name
    mediator of DNA damage checkpoint 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060810-185
    See related
    Ensembl:ENSDARG00000086764 AllianceGenome:ZFIN:ZDB-GENE-060810-185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:eu278; im:7163673; si:ch73-309n4.5
    Summary
    Predicted to be involved in positive regulation of transcription initiation by RNA polymerase II. Predicted to be located in chromosome. Predicted to be active in nucleus. Orthologous to human MDC1 (mediator of DNA damage checkpoint 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mdc1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (10329725..10346133)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (10438791..10455226)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene flotillin 1b Neighboring gene tubulin, beta 5 Neighboring gene si:dkeyp-77h1.4 Neighboring gene uncharacterized LOC108179567 Neighboring gene uncharacterized LOC100534757

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mediator of DNA damage checkpoint protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365560.1 → NP_001352489.1  mediator of DNA damage checkpoint protein 1

      Status: VALIDATED

      Source sequence(s)
      CR848747, CU984574, FP016064
      UniProtKB/TrEMBL
      A0A8N7T6W3, E7FA74
      Related
      ENSDARP00000106038.1, ENSDART00000121966.3
      Conserved Domains (5) summary
      smart00292
      Location:1805 → 1876
      BRCT; breast cancer carboxy-terminal domain
      cd00060
      Location:30 → 139
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl00038
      Location:1681 → 1780
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cl26511
      Location:936 → 1498
      Neuromodulin_N; Gap junction protein N-terminal region
      cl26761
      Location:343 → 677
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    2. NM_001365561.1 → NP_001352490.1  mediator of DNA damage checkpoint protein 1

      Status: VALIDATED

      Source sequence(s)
      CR848747, CU984574, FP016064
      UniProtKB/TrEMBL
      A0A8N7T6W3, E7FA74
      Related
      ENSDARP00000142518.1, ENSDART00000172845.2
      Conserved Domains (5) summary
      smart00292
      Location:1805 → 1876
      BRCT; breast cancer carboxy-terminal domain
      cd00060
      Location:30 → 139
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl00038
      Location:1681 → 1780
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cl26511
      Location:936 → 1498
      Neuromodulin_N; Gap junction protein N-terminal region
      cl26761
      Location:343 → 677
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      10329725..10346133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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