jam3b junctional adhesion molecule 3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: jam3bprovided by ZNC
Official Full Name: junctional adhesion molecule 3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-441
See related: Ensembl:ENSDARG00000061794 AllianceGenome:ZFIN:ZDB-GENE-030131-441
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: psr; jam3; JAM-C; sr:nyz155; wu:fb30h11; wu:fc08c06; wu:fc13e04; wu:fc25g11
Summary: Predicted to enable cell-cell adhesion mediator activity and integrin binding activity. Acts upstream of or within with a positive effect on myoblast fusion. Predicted to be located in bicellular tight junction; desmosome; and membrane. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in cell-cell contact zone and plasma membrane. Is expressed in several structures, including cardiovascular system; hypodermis; musculature system; myoblast; and nervous system. Orthologous to human JAM3 (junctional adhesion molecule 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (24984965..25043911)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (24948360..25007306)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Jam3b plays dual roles in hemato-vascular development during early embryogenesis: it promotes endothelial specification in mesodermal cells via the regulation of npas4l, and it confers the hematopoietic fate in endothelial precursors through the regulation of Leucine rich repeat containing 15 (Lrrc15)
Title: Dual role of Jam3b in early hematopoietic and vascular development.
The studies demonstrate that although Jamb, Jamc, and Mymk are all involved in myoblast fusion during early myogenesis, they have distinct roles in myoblast fusion during muscle growth. While Mymk is essential for myoblast fusion during both muscle development and growth, Jamb and Jamc are dispensable for myoblast fusion during muscle growth.
Title: Genetic Mutations in jamb, jamc, and myomaker Revealed Different Roles on Myoblast Fusion and Muscle Growth.
interaction between Jamb and Jamc expressed by neighbouring cells is essential for fusion. jamc is ectopically expressed in prdm1a mutant slow muscle precursors, which inappropriately fuse with other myocytes.
Title: Jamb and jamc are essential for vertebrate myocyte fusion.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fb30h11 (e-PCR)
- UniSTS:189018

fc13e04.x1 (e-PCR)
- UniSTS:187753

AI322201 (e-PCR)
- UniSTS:206835

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myoblast fusion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
is_active_in cell-cell contact zone	IBA Inferred from Biological aspect of Ancestor more info
located_in desmosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein complex involved in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: junctional adhesion molecule 3B

Names: jamc; jamc.1; junctional adhesion molecule 3; junctional adhesion molecule C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082863.3 → NP_001076332.2 junctional adhesion molecule 3B

Status: PROVISIONAL

Source sequence(s)

BC134233

UniProtKB/Swiss-Prot

A3KPA0

Related

ENSDARP00000082979.5, ENSDART00000088546.7

Conserved Domains (4) summary

cd00096
Location:160 → 235

Ig; Immunoglobulin domain

smart00410
Location:51 → 139

IG_like; Immunoglobulin like

pfam07679
Location:143 → 234

I-set; Immunoglobulin I-set domain

cl11960
Location:51 → 121

Ig; Immunoglobulin domain