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    srpra SRP receptor subunit alpha [ Danio rerio (zebrafish) ]

    Gene ID: 569063, updated on 9-Dec-2024

    Summary

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    Official Symbol
    srpraprovided by ZNC
    Official Full Name
    SRP receptor subunit alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030219-11
    See related
    Ensembl:ENSDARG00000061124 AllianceGenome:ZFIN:ZDB-GENE-030219-11
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    srpr; id:ibd1064; wu:fd12f02
    Summary
    Predicted to enable GTPase activity and signal recognition particle binding activity. Acts upstream of or within neutrophil differentiation. Predicted to be part of signal recognition particle receptor complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in brain. Orthologous to human SRPRA (SRP receptor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See srpra in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (44826173..44847801, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (44832719..44854401, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene ilvB (bacterial acetolactate synthase)-like Neighboring gene family with sequence similarity 118 member B Neighboring gene ADP-ribosylation factor GTPase activating protein 2 Neighboring gene si:ch211-71n6.4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes. Linder MI, et al. Blood, 2023 Feb 9. PMID 36223592, Free PMC Article
    2. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
    3. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    4. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signal recognition particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal recognition particle binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neutrophil differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle receptor subunit alpha
    Names
    signal recognition particle receptor (docking protein)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      44826173..44847801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_692426.10 → XP_697518.3  signal recognition particle receptor subunit alpha

      UniProtKB/TrEMBL
      A0A8N7UW26, E7EZW6
      Related
      ENSDARP00000081257.5, ENSDART00000086823.6
      Conserved Domains (4) summary
      smart00963
      Location:336 → 409
      SRP54_N; SRP54-type protein, helical bundle domain
      cd03115
      Location:431 → 627
      SRP; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The ...
      TIGR00064
      Location:348 → 647
      ftsY; signal recognition particle-docking protein FtsY
      pfam04086
      Location:29 → 297
      SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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