fignl2 fidgetin like 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fignl2provided by ZNC
Official Full Name: fidgetin like 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-090313-189
See related: Ensembl:ENSDARG00000057062 AllianceGenome:ZFIN:ZDB-GENE-090313-189
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc13c02; wu:fc13c02; si:dkey-157g16.6
Summary: Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Involved in morphogenesis of a branching structure. Predicted to be located in cell cortex. Is expressed in several structures, including axis; hindbrain neural rod; nervous system; pectoral fin bud; and solid lens vesicle. Orthologous to human FIGNL2 (fidgetin like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (27131654..27245023, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (27205113..27226325, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc13c02.x1 (e-PCR)
- UniSTS:187750

fc05a03.y1 (e-PCR)
- UniSTS:192187

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables microtubule severing ATPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule severing	ISS Inferred from Sequence or Structural Similarity more info
involved_in morphogenesis of a branching structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fidgetin-like protein 2

NP_001201837.1

EC 3.6.4.-

XP_068072876.1

EC 3.6.4.-

XP_068072877.1

EC 3.6.4.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001214908.1 → NP_001201837.1 fidgetin-like protein 2

See identical proteins and their annotated locations for NP_001201837.1

Status: VALIDATED

Source sequence(s)

CR354433

UniProtKB/Swiss-Prot

A0A8M1NZ11, E9QEA3

Conserved Domains (2) summary

smart00382
Location:457 → 583

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:461 → 581

AAA; ATPase family associated with various cellular activities (AAA)