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    elavl4 ELAV like neuron-specific RNA binding protein 4 [ Danio rerio (zebrafish) ]

    Gene ID: 30737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elavl4provided by ZNC
    Official Full Name
    ELAV like neuron-specific RNA binding protein 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-246
    See related
    Ensembl:ENSDARG00000045639 AllianceGenome:ZFIN:ZDB-GENE-990415-246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hud; elrd; wu:fc24h01
    Summary
    Predicted to enable RNA binding activity. Acts upstream of or within axonogenesis. Part of protein-containing complex. Is expressed in heart; nervous system; swim bladder; and trigeminal placode. Orthologous to human ELAVL4 (ELAV like RNA binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See elavl4 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (16004154..16116003)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (15968415..16080291)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene BEN domain containing 5 Neighboring gene AGBL carboxypeptidase 4 Neighboring gene DMRT-like family A2 Neighboring gene Fas (TNFRSF6) associated factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Comparative Analysis of Gene and Protein Expression Throughout a Full 28-Day Retinal Regeneration Time-Course in Adult Zebrafish. Kramer AC, et al. Front Cell Dev Biol, 2021. PMID 34790663, Free PMC Article
    2. HuD and the Survival Motor Neuron Protein Interact in Motoneurons and Are Essential for Motoneuron Development, Function, and mRNA Regulation. Hao le T, et al. J Neurosci, 2017 Nov 29. PMID 29061699, Free PMC Article
    3. DeltaA mRNA and protein distribution in the zebrafish nervous system. Tallafuss A, et al. Dev Dyn, 2009 Dec. PMID 19924821, Free PMC Article
    4. Regulation of hub mRNA stability and translation by miR430 and the dead end protein promotes preferential expression in zebrafish primordial germ cells. Mickoleit M, et al. Dev Dyn, 2011 Mar. PMID 21337467
    5. Deeply conserved chordate noncoding sequences preserve genome synteny but do not drive gene duplicate retention. Hufton AL, et al. Genome Res, 2009 Nov. PMID 19704032, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HuD is necessary for motor axonal branch and dendrite formation.
      Title: HuD and the Survival Motor Neuron Protein Interact in Motoneurons and Are Essential for Motoneuron Development, Function, and mRNA Regulation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within axonogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ELAV-like protein 4
    Names
    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
    elav-related D
    embryonic lethal, abnormal vision-related D
    protein elrD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244600.1 → NP_001231529.1  ELAV-like protein 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC065965, CR931780, CU467068
      UniProtKB/Swiss-Prot
      A0A0R4IEW8, Q6NZU5, Q90409
      UniProtKB/TrEMBL
      A0A8M9Q9I0
      Related
      ENSDARP00000133629.2, ENSDART00000172510.2
      Conserved Domains (1) summary
      TIGR01661
      Location:85 → 410
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    2. NM_001244601.1 → NP_001231530.1  ELAV-like protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus and is shorter compared to isoform 1.
      Source sequence(s)
      BC065965, CR931780, CU467068
      UniProtKB/TrEMBL
      A0A8M9Q9I0
      Conserved Domains (1) summary
      TIGR01661
      Location:72 → 397
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    3. NM_131453.3 → NP_571528.2  ELAV-like protein 4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter compared to isoform 1.
      Source sequence(s)
      BC065965, CU467068
      UniProtKB/TrEMBL
      A0A8M9Q9I0, F1QGR7
      Related
      ENSDARP00000098371.3, ENSDART00000110171.5
      Conserved Domains (1) summary
      TIGR01661
      Location:77 → 402
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      16004154..16116003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222857.1 → XP_068078958.1  ELAV-like protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QIF9

    2. XM_068222859.1 → XP_068078960.1  ELAV-like protein 4 isoform X4

      UniProtKB/TrEMBL
      A0A8M9QIF9
      Related
      ENSDARP00000141994.2, ENSDART00000165141.2

    3. XM_068222856.1 → XP_068078957.1  ELAV-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q9I0

    4. XM_068222858.1 → XP_068078959.1  ELAV-like protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q9I0

    5. XM_068222860.1 → XP_068078961.1  ELAV-like protein 4 isoform X5

      UniProtKB/Swiss-Prot
      A0A0R4IEW8, Q6NZU5, Q90409
      UniProtKB/TrEMBL
      A0A8M9Q9I0

    6. XM_068222863.1 → XP_068078964.1  ELAV-like protein 4 isoform X8

      UniProtKB/TrEMBL
      A0A8M2BEA7, A0A8M9Q9I0

    7. XM_068222862.1 → XP_068078963.1  ELAV-like protein 4 isoform X7

      UniProtKB/TrEMBL
      A0A8M9Q9I0

    8. XM_068222865.1 → XP_068078966.1  ELAV-like protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A8M6Z808, A0A8M9Q9I0

    9. XM_068222861.1 → XP_068078962.1  ELAV-like protein 4 isoform X6

      UniProtKB/TrEMBL
      A0A8M9Q9I0, F1QGR7

    10. XM_068222864.1 → XP_068078965.1  ELAV-like protein 4 isoform X9

      UniProtKB/TrEMBL
      A0A8M9Q9I0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0R4IEW8.2 GenPept UniProtKB/Swiss-Prot:A0A0R4IEW8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.