ass1 argininosuccinate synthase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ass1provided by ZNC
Official Full Name: argininosuccinate synthase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040912-178
See related: Ensembl:ENSDARG00000103044 AllianceGenome:ZFIN:ZDB-GENE-040912-178
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ass; zgc:92051; wu:fb95a04; wu:fc01e08
Summary: Predicted to enable argininosuccinate synthase activity. Predicted to be involved in L-arginine biosynthetic process; argininosuccinate metabolic process; and urea cycle. Predicted to act upstream of or within amino acid biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including DEL; ball; brain; endoderm; and forerunner cell group. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	Unplaced Scaffold	NW_003334318.1 (11222..55305)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003334318.1 (11222..55305)

NW_003334318.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ASS1 deficiency is associated with impaired neuronal differentiation in zebrafish larvae.
Title: ASS1 deficiency is associated with impaired neuronal differentiation in zebrafish larvae.

Submit: New GeneRIF Correction

General gene information

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Markers

fb17h03.x1 (e-PCR)
- UniSTS:190219

fc01e08.x1 (e-PCR)
- UniSTS:192044

fc44a03.x1 (e-PCR)
- UniSTS:193871

AI588409 (e-PCR)
- UniSTS:206199

fc23d08.x1 (e-PCR)
- UniSTS:193148

fc28d06.x1 (e-PCR)
- UniSTS:193407

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables argininosuccinate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables argininosuccinate synthase activity	IEA Inferred from Electronic Annotation more info
enables argininosuccinate synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-arginine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-arginine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-arginine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-arginine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in argininosuccinate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in urea cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within urea cycle	IEA Inferred from Electronic Annotation more info
involved_in urea cycle	IEA Inferred from Electronic Annotation more info
involved_in urea cycle	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: argininosuccinate synthase

Names: argininosuccinate synthetase 1; citrulline--aspartate ligase

NP_001004603.1

EC 6.3.4.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004603.1 → NP_001004603.1 argininosuccinate synthase

See identical proteins and their annotated locations for NP_001004603.1

Status: PROVISIONAL

Source sequence(s)

BC081578

UniProtKB/Swiss-Prot

Q66I24

Related

ENSDARP00000140635.2, ENSDART00000170382.2

Conserved Domains (1) summary

cd01999
Location:6 → 397

Argininosuccinate_Synthase; Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In ...