wnt2 wingless-type MMTV integration site family member 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wnt2provided by ZNC
Official Full Name: wingless-type MMTV integration site family member 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-416
See related: Ensembl:ENSDARG00000041117 AllianceGenome:ZFIN:ZDB-GENE-980526-416
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wnt-2; ZfWnt2
Summary: Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within hepatocyte proliferation and swim bladder development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including nervous system; optic cup; optic vesicle; otic vesicle; and swim bladder bud. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (20613241..20636525, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (20624175..20647459, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

show that sequential functions of Wnt2bb and Wnt2 control liver specification and proliferation in zebrafish
Title: Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development.

Submit: New GeneRIF Correction

General gene information

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Markers

wnt2 (e-PCR), detects polymorphism
- UniSTS:205468

wnt2 (e-PCR), detects polymorphism
- UniSTS:187052

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration involved in gastrulation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within swim bladder development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within swim bladder development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-2

Names: etID309852.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.