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    tmod4 tropomodulin 4 (muscle) [ Danio rerio (zebrafish) ]

    Gene ID: 30441, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmod4provided by ZNC
    Official Full Name
    tropomodulin 4 (muscle)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-991019-9
    See related
    Ensembl:ENSDARG00000020890 AllianceGenome:ZFIN:ZDB-GENE-991019-9
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sktmod; Sk-Tmod; fa12b03; wu:fa12b03
    Summary
    Predicted to enable tropomyosin binding activity. Acts upstream of or within skeletal myofibril assembly. Predicted to be active in striated muscle thin filament. Is expressed in head muscle and myotome. Orthologous to human TMOD4 (tropomodulin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tmod4 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (29650738..29684193)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (29716115..29749570)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene MCL1 apoptosis regulator, BCL2 family member b Neighboring gene vacuolar protein sorting 72 homolog b Neighboring gene uncharacterized LOC137487915 Neighboring gene sodium channel modifier 1 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy. Berger J, et al. Dis Model Mech, 2014 Dec. PMID 25288681, Free PMC Article
    2. Genetic dissection of novel myopathy models reveals a role of CapZα and Leiomodin 3 during myofibril elongation. Berger J, et al. PLoS Genet, 2022 Feb. PMID 35148320, Free PMC Article
    3. Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. Lange M, et al. Genes Dev, 2008 Sep 1. PMID 18765789, Free PMC Article
    4. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170
    5. Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise. Boskovic S, et al. PLoS One, 2018. PMID 30252882, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMOD4 is a novel candidate for unresolved nemaline myopathies; the tmod4(trg) mutant may be a valuable tool to study human muscle disorders
      Title: Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tropomyosin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pointed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within skeletal myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in striated muscle thin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tropomodulin-4
    Names
    skeletal tropomodulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131196.2 → NP_571271.1  tropomodulin-4

      See identical proteins and their annotated locations for NP_571271.1

      Status: VALIDATED

      Source sequence(s)
      CT954330, EB768043, EH434020, EH602087
      UniProtKB/TrEMBL
      A0A2R8QJ05, F6P9H6, Q9PUQ6
      Related
      ENSDARP00000112954.1, ENSDART00000137153.2
      Conserved Domains (2) summary
      cd00116
      Location:235 → 314
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam03250
      Location:4 → 140
      Tropomodulin; Tropomodulin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      29650738..29684193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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