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    nktr natural killer cell triggering receptor [ Danio rerio (zebrafish) ]

    Gene ID: 323005, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nktrprovided by ZNC
    Official Full Name
    natural killer cell triggering receptorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1725
    See related
    Ensembl:ENSDARG00000059097 AllianceGenome:ZFIN:ZDB-GENE-030131-1725
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb78g10; wu:fb82h03
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to act upstream of or within protein peptidyl-prolyl isomerization. Predicted to be active in mitochondrion and nucleus. Orthologous to human NKTR (natural killer cell triggering receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nktr in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (20643662..20658437, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (20499238..20514039, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene kelch-like family member 40b Neighboring gene zinc finger and BTB domain containing 47b Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene vasoactive intestinal peptide receptor 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Impaired Lymphocytes Development and Xenotransplantation of Gastrointestinal Tumor Cells in Prkdc-Null SCID Zebrafish Model. Jung IH, et al. Neoplasia, 2016 Aug. PMID 27566103, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NK-tumor recognition protein
    Names
    natural killer-tumor recognition sequence
    XP_001338072.4
    XP_005162782.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      20643662..20658437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001338036.7 → XP_001338072.4  NK-tumor recognition protein isoform X1

      UniProtKB/TrEMBL
      A0A8M1Q7A9, A0A8M3AW09, E7F5I0
      Related
      ENSDARP00000107238.2, ENSDART00000127923.4
      Conserved Domains (1) summary
      cl00197
      Location:7 → 174
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    2. XM_005162725.4 → XP_005162782.1  NK-tumor recognition protein isoform X2

      UniProtKB/TrEMBL
      A0A8M2B9X7, A0A8M3AW09
      Conserved Domains (1) summary
      pfam00160
      Location:1 → 63
      Pro_isomerase; Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
    Nucleotide Protein Strain
    Heading Accession and Version

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