tspan6 tetraspanin 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tspan6provided by ZNC
Official Full Name: tetraspanin 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5435
See related: Ensembl:ENSDARG00000015759 AllianceGenome:ZFIN:ZDB-GENE-030131-5435
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tm4sf2; tspan7; zgc:63823; wu:fa11g01; wu:fd18e11; wu:fl39g07
Summary: Acts upstream of with a positive effect on organelle assembly. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 58. Orthologous to several human genes including TSPAN6 (tetraspanin 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (41469478..41478369, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (41102224..41111055, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fa11g01.r1 (e-PCR)
- UniSTS:189586

fd18e11.x1 (e-PCR)
- UniSTS:204226

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect organelle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tetraspanin-6

Names: tetraspanin 7; tm4sf2a; transmembrane 4 superfamily member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214774.2 → NP_999939.1 tetraspanin-6

See identical proteins and their annotated locations for NP_999939.1

Status: VALIDATED

Source sequence(s)

BQ262702, CU459160

UniProtKB/TrEMBL

B2GRG0, Q7SXT2

Related

ENSDARP00000018978.8, ENSDART00000016002.11

Conserved Domains (2) summary

cd03161
Location:112 → 215

TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:16 → 243

Tetraspannin; Tetraspanin family