myclb MYCL proto-oncogene, bHLH transcription factor b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myclbprovided by ZNC
Official Full Name: MYCL proto-oncogene, bHLH transcription factor bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5561
See related: Ensembl:ENSDARG00000034956 AllianceGenome:ZFIN:ZDB-GENE-030131-5561
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mycl1b; fi04c04; wu:fa07c04; wu:fb19f03; wu:fi04c04; zgc:152988; si:ch211-194e15.2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in nervous system; pectoral fin; pectoral fin bud; pharyngeal arch; and presumptive neural retina. Orthologous to several human genes including MYCL (MYCL proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (30805513..30811161, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (31218200..31223848, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb19f03.x1 (e-PCR)
- UniSTS:203037

AA542457 (e-PCR)
- UniSTS:206924

fi04c04.x1 (e-PCR)
- UniSTS:204418

D1S3694 (e-PCR)
- UniSTS:474272

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein L-Myc-1b

Names: V-Myc1; v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog b; v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045142.1 → NP_001038607.1 protein L-Myc-1b

See identical proteins and their annotated locations for NP_001038607.1

Status: PROVISIONAL

Source sequence(s)

BX547927

UniProtKB/Swiss-Prot

Q1LWL8

UniProtKB/TrEMBL

B2GPV7

Related

ENSDARP00000094300.4, ENSDART00000103524.5

Conserved Domains (2) summary

cd00083
Location:319 → 374

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam01056
Location:18 → 283

Myc_N; Myc amino-terminal region