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    fkbp4 FKBP prolyl isomerase 4 [ Danio rerio (zebrafish) ]

    Gene ID: 321795, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fkbp4provided by ZNC
    Official Full Name
    FKBP prolyl isomerase 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-514
    See related
    Ensembl:ENSDARG00000008447 AllianceGenome:ZFIN:ZDB-GENE-030131-514
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb34f09
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to be active in cytoplasm. Orthologous to human FKBP4 (FKBP prolyl isomerase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fkbp4 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (6536340..6550378)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (6395922..6410013)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene WAS protein family homolog 1 Neighboring gene DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 3b Neighboring gene troponin I, skeletal, slow c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Functional Comparison of Human and Zebra Fish FKBP52 Confirms the Importance of the Proline-Rich Loop for Regulation of Steroid Hormone Receptor Activity. Harris DC, et al. Int J Mol Sci, 2019 Oct 28. PMID 31661769, Free PMC Article
    2. Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy. Giustiniani J, et al. Proc Natl Acad Sci U S A, 2014 Mar 25. PMID 24623856, Free PMC Article
    3. FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium. Li Y, et al. FEBS Lett, 2023 Jul. PMID 37259581
    4. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT acts_upstream_of_or_within regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP4
    Names
    FK506 binding protein 4
    FKBP52
    NP_958877.1
    XP_005173673.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201469.1 → NP_958877.1  peptidyl-prolyl cis-trans isomerase FKBP4

      See identical proteins and their annotated locations for NP_958877.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045387
      UniProtKB/TrEMBL
      Q7ZVW2
      Related
      ENSDARP00000013076.7, ENSDART00000024576.9
      Conserved Domains (6) summary
      TIGR03516
      Location:153 → 249
      ppisom_GldI; peptidyl-prolyl isomerase, gliding motility-associated
      sd00006
      Location:269 → 293
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:38 → 129
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam00515
      Location:316 → 347
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:316 → 379
      TPR_11; TPR repeat
      pfam13432
      Location:270 → 348
      TPR_16; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      6536340..6550378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173616.5 → XP_005173673.1  peptidyl-prolyl cis-trans isomerase FKBP4 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BKV5, F8W2D1
      Related
      ENSDARP00000124772.1, ENSDART00000149350.2
      Conserved Domains (6) summary
      TIGR03516
      Location:153 → 249
      ppisom_GldI; peptidyl-prolyl isomerase, gliding motility-associated
      sd00006
      Location:269 → 293
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:38 → 129
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam00515
      Location:316 → 347
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:316 → 379
      TPR_11; TPR repeat
      pfam13432
      Location:270 → 348
      TPR_16; Tetratricopeptide repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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