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    sptbn1 spectrin, beta, non-erythrocytic 1 [ Danio rerio (zebrafish) ]

    Gene ID: 553451, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sptbn1provided by ZNC
    Official Full Name
    spectrin, beta, non-erythrocytic 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031006-3
    See related
    Ensembl:ENSDARG00000102883 AllianceGenome:ZFIN:ZDB-GENE-031006-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb30a06; fb92e08; wu:fb30a06; wu:fb92e08; si:zfos-1837d3.1
    Summary
    Predicted to enable actin binding activity and phospholipid binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in actin filament capping. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Predicted to be part of spectrin. Orthologous to human SPTBN1 (spectrin beta, non-erythrocytic 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sptbn1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (43132519..43226250, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (42840438..42933790, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene acylphosphatase 2, muscle type Neighboring gene forkhead box G1b Neighboring gene uncharacterized LOC137496738 Neighboring gene sulfotransferase family, cytosolic, 6b, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Choe SK, et al. Dev Biol, 2011 Oct 15. PMID 21787765, Free PMC Article
    2. Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Farnsworth DR, et al. Exp Eye Res, 2021 May. PMID 33705730, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spectrin IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spectrin beta chain, non-erythrocytic 1
    Names
    zmp:0000000587
    zmp:0000000859

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365192.1 → NP_001352121.1  spectrin beta chain, non-erythrocytic 1

      Status: VALIDATED

      Source sequence(s)
      CU655835, FO704577, FO834831, FP017152
      UniProtKB/TrEMBL
      A0A8M3BDW6
      Related
      ENSDARP00000138563.1, ENSDART00000164700.2
      Conserved Domains (4) summary
      COG5069
      Location:2 → 455
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:451 → 664
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:2104 → 2209
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00435
      Location:1937 → 1995
      Spectrin; Spectrin repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      43132519..43226250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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