glud1a glutamate dehydrogenase 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: glud1aprovided by ZNC
Official Full Name: glutamate dehydrogenase 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030114-2
See related: Ensembl:ENSDARG00000008816 AllianceGenome:ZFIN:ZDB-GENE-030114-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb622; glud1; zgc:77186; wu:fc33g09; wu:fc66a10
Summary: Predicted to enable glutamate dehydrogenase (NAD+) activity. Predicted to be involved in glutamate catabolic process. Predicted to act upstream of or within amino acid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including cardiovascular system; digestive system; nervous system; periderm; and pronephros. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to several human genes including GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (22679083..22699024, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (22548633..22568574, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc33g09.x1 (e-PCR)
- UniSTS:188019

fc66a10.x1 (e-PCR)
- UniSTS:203985

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glutamate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutamate catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutamate dehydrogenase 1a

NP_997741.1

EC 1.4.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212576.1 → NP_997741.1 glutamate dehydrogenase 1a

See identical proteins and their annotated locations for NP_997741.1

Status: PROVISIONAL

Source sequence(s)

BC066370

UniProtKB/TrEMBL

Q6NZ29

Related

ENSDARP00000008646.8, ENSDART00000016946.10

Conserved Domains (3) summary

cd01076
Location:249 → 534

NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1

pfam00208
Location:249 → 540

ELFV_dehydrog; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase

pfam02812
Location:99 → 226

ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain