wwp2 WW domain containing E3 ubiquitin protein ligase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wwp2provided by ZNC
Official Full Name: WW domain containing E3 ubiquitin protein ligase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-000607-82
See related: Ensembl:ENSDARG00000061345 AllianceGenome:ZFIN:ZDB-GENE-000607-82
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: id:ibd1121; wu:fo87e10; zgc:154036
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and ubiquitin protein ligase activity. Acts upstream of or within roof of mouth development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in brain; germ ring; head; pectoral fin bud; and tail bud. Orthologous to human WWP2 (WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (34749179..34804029)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (34243127..34299071)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: NEDD4-like E3 ubiquitin-protein ligase WWP2

NP_001092918.1

EC 2.3.2.26

XP_005163228.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099448.1 → NP_001092918.1 NEDD4-like E3 ubiquitin-protein ligase WWP2

See identical proteins and their annotated locations for NP_001092918.1

Status: PROVISIONAL

Source sequence(s)

BC129043

UniProtKB/TrEMBL

A0A2R8RWE6, A0A8M6Z4C8, A2VCZ7, F6PEA4

Related

ENSDARP00000154551.1, ENSDART00000185712.1

Conserved Domains (5) summary

cd04021
Location:17 → 145

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

smart00456
Location:297 → 326

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:535 → 863

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:512 → 864

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:402 → 430

WW; WW domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

34749179..34804029

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163171.5 → XP_005163228.1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

UniProtKB/TrEMBL

A0A8M2BAJ0, A0A8M6Z4C8, F6P346

Related

ENSDARP00000081798.4, ENSDART00000087364.6

Conserved Domains (5) summary

cd04021
Location:17 → 145

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

smart00456
Location:298 → 327

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:536 → 864

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:513 → 865

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:403 → 431

WW; WW domain