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    badb BCL2 associated agonist of cell death b [ Danio rerio (zebrafish) ]

    Gene ID: 58100, updated on 9-Dec-2024

    Summary

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    Official Symbol
    badbprovided by ZNC
    Official Full Name
    BCL2 associated agonist of cell death bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000616-1
    See related
    Ensembl:ENSDARG00000054937 AllianceGenome:ZFIN:ZDB-GENE-000616-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bad; fa01b12; wu:fa01b12; wu:fa96d04
    Summary
    Acts upstream of or within cellular response to ionizing radiation and positive regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including brain; hindbrain neural plate; immature eye; midbrain hindbrain boundary neural keel; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human BAD (BCL2 associated agonist of cell death). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See badb in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (25129520..25135818, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (24858363..24864601, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene zgc:101765 Neighboring gene glycoprotein hormone subunit alpha 2 Neighboring gene membrane anchored junction protein Neighboring gene exocyst complex component 6B Neighboring gene cytochrome P450, family 26, subfamily b, polypeptide 1 Neighboring gene dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) Neighboring gene uncharacterized LOC137496166

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos. Hsieh YC, et al. Biochem Biophys Res Commun, 2003 May 16. PMID 12727206
    2. GLUT1 deficiency links nutrient availability and apoptosis during embryonic development. Jensen PJ, et al. J Biol Chem, 2006 May 12. PMID 16543226
    3. Interdependence of Bad and Puma during ionizing-radiation-induced apoptosis. Toruno C, et al. PLoS One, 2014. PMID 24516599, Free PMC Article
    4. Aquatic birnavirus capsid protein, VP3, induces apoptosis via the Bad-mediated mitochondria pathway in fish and mouse cells. Chiu CL, et al. Apoptosis, 2010 Jun. PMID 20131002
    5. Developmental toxicity and apoptosis in zebrafish embryos induced by low-dose γ-ray irradiation. Zhao W, et al. Environ Sci Pollut Res Int, 2019 Feb. PMID 30539402

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Proapoptotic Gene Bad Regulates Brain Development via p53-Mediated Stress Signals in Zebrafish.
      Title: The Proapoptotic Gene Bad Regulates Brain Development via p53-Mediated Stress Signals in Zebrafish.
    2. Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish.
      Title: Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish.
    3. Bad functions as an essential sensitizer and Puma as an essential activator of IR-induced mitochondrial apoptosis specifically in embryonic neural tissue.
      Title: Interdependence of Bad and Puma during ionizing-radiation-induced apoptosis.
    4. Stage-specific expression of TNFalpha regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells.
      Title: Stage-specific expression of TNFα regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells.
    5. Results indicate that zebrafish BH3-only proapoptotic protein (BAD) could induce apoptosis in vitro and in vivo and may have biological implications in apoptosis during zebrafish development.
      Title: Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to ionizing radiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BCL2 associated agonist of cell death b
    Names
    BCL2-antagonist of cell death b
    proapoptotic BH3-only protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270595.1 → NP_001257524.1  BCL2 associated agonist of cell death b isoform 1

      See identical proteins and their annotated locations for NP_001257524.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AA495398, EH561412, EH592357
      UniProtKB/TrEMBL
      B2GR09, Q4V925
      Related
      ENSDARP00000071687.3, ENSDART00000077219.5
      Conserved Domains (1) summary
      pfam10514
      Location:51 → 135
      Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD

    2. NM_131579.2 → NP_571654.1  BCL2 associated agonist of cell death b isoform 2

      See identical proteins and their annotated locations for NP_571654.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AA495398, EH498043, EH561412
      UniProtKB/TrEMBL
      A0A8N1Z227, Q9I9N2
      Related
      ENSDARP00000106381.1, ENSDART00000121943.3
      Conserved Domains (1) summary
      pfam10514
      Location:51 → 134
      Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      25129520..25135818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172305.5 → XP_005172362.1  BCL2 associated agonist of cell death b isoform X1

      See identical proteins and their annotated locations for XP_005172362.1

      UniProtKB/TrEMBL
      B2GR09, Q4V925
      Conserved Domains (1) summary
      pfam10514
      Location:51 → 135
      Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394690.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      99754..104047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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