swap70b switching B cell complex subunit SWAP70b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: swap70bprovided by ZNC
Official Full Name: switching B cell complex subunit SWAP70bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3587
See related: Ensembl:ENSDARG00000057286 AllianceGenome:ZFIN:ZDB-GENE-030131-3587
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: swp70; fc45f07; wu:fc45f07; si:dkey-8l13.4
Summary: Predicted to enable calcium ion binding activity. Acts upstream of or within convergent extension; positive regulation of oligodendrocyte differentiation; and regulation of exit from mitosis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including immature eye; mesoderm; nervous system; pectoral fin; and vasculature. Orthologous to human SWAP70 (switching B cell complex subunit SWAP70). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (16876833..16916840, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (16887767..16927774, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Swap70b and Def6a delineate Wnt11 and Wnt5b signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation
Title: Swap70b is required for convergent and extension cell movement during zebrafish gastrulation linking Wnt11 signalling and RhoA effector function.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within convergent extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: switch-associated protein 70b

Names: SWAP switching B-cell complex 70b subunit 70b; SWAP switching B-cell complex subunit 70b; switch-associated protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044986.1 → NP_001038451.1 switch-associated protein 70b

Status: PROVISIONAL

Source sequence(s)

BX005395

UniProtKB/TrEMBL

A0A8M1N9S3, Q1LYE0

Related

ENSDARP00000090877.4, ENSDART00000100105.6

Conserved Domains (3) summary

cd13273
Location:203 → 312

PH_SWAP-70; Switch-associated protein-70 Pleckstrin homology (PH) domain

pfam00169
Location:210 → 304

PH; PH domain

cl02488
Location:410 → 526

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...