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    eif4e1c eukaryotic translation initiation factor 4E family member 1c [ Danio rerio (zebrafish) ]

    Gene ID: 550549, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif4e1cprovided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 4E family member 1cprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-398
    See related
    Ensembl:ENSDARG00000012274 AllianceGenome:ZFIN:ZDB-GENE-050417-398
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb57e09; eif4E-1C; wu:fb57e09; zgc:110154
    Summary
    Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 4F complex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eif4e1c in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (18311471..18324469)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (18180479..18193477)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 16 Neighboring gene tet methylcytosine dioxygenase 1 Neighboring gene uncharacterized LOC110440176 Neighboring gene si:dkey-228d14.5 Neighboring gene uncharacterized LOC137487384 Neighboring gene zgc:110319

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A comparative genomics study of carbohydrate/glucose metabolic genes: from fish to mammals. Zhang Y, et al. BMC Genomics, 2018 Apr 11. PMID 29642853, Free PMC Article
    2. The translation initiation factor homolog eif4e1c regulates cardiomyocyte metabolism and proliferation during heart regeneration. Rao A, et al. Development, 2023 Oct 15. PMID 37306388, Free PMC Article
    3. Phylogenetic analysis of eIF4E-family members. Joshi B, et al. BMC Evol Biol, 2005 Sep 28. PMID 16191198, Free PMC Article
    4. eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs. Lorenzo-Orts L, et al. EMBO Rep, 2024 Jan. PMID 38177902, Free PMC Article
    5. Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. Frank DF, et al. PeerJ, 2017. PMID 29201571, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The translation initiation factor homolog eif4e1c regulates cardiomyocyte metabolism and proliferation during heart regeneration.
      Title: The translation initiation factor homolog eif4e1c regulates cardiomyocyte metabolism and proliferation during heart regeneration.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E family member 1c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017851.2 → NP_001017851.2  eukaryotic translation initiation factor 4E family member 1c

      See identical proteins and their annotated locations for NP_001017851.2

      Status: PROVISIONAL

      Source sequence(s)
      BC155151
      UniProtKB/TrEMBL
      A0A8M1N5I2, A9JT06
      Related
      ENSDARP00000031553.7, ENSDART00000036718.9
      Conserved Domains (1) summary
      pfam01652
      Location:37 → 193
      IF4E; Eukaryotic initiation factor 4E

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      18311471..18324469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156639.5 → XP_005156696.1  eukaryotic translation initiation factor 4E family member 1c isoform X1

      UniProtKB/TrEMBL
      A0A8M2B2Z0, B8A6A1
      Related
      ENSDARP00000119224.1, ENSDART00000132073.3
      Conserved Domains (1) summary
      pfam01652
      Location:54 → 210
      IF4E; Eukaryotic initiation factor 4E

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394875.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      257732..270729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.