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    tecrb trans-2,3-enoyl-CoA reductase b [ Danio rerio (zebrafish) ]

    Gene ID: 326954, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tecrbprovided by ZNC
    Official Full Name
    trans-2,3-enoyl-CoA reductase bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5154
    See related
    Ensembl:ENSDARG00000025904 AllianceGenome:ZFIN:ZDB-GENE-030131-5154
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb250; gpsn2; sb:cb250; mg:db03b10; wu:fj63b12
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in very long-chain fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including digestive system; eye; forebrain; musculature system; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 14. Orthologous to human TECR (trans-2,3-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tecrb in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (55752643..55779096)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (55074992..55099503)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E3-like Neighboring gene adhesion G protein-coupled receptor E10 Neighboring gene DnaJ heat shock protein family (Hsp40) member B1b Neighboring gene NADH:ubiquinone oxidoreductase subunit B7 Neighboring gene zgc:136908

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish. Howarth DL, et al. PLoS Genet, 2014. PMID 24874946, Free PMC Article
    2. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article
    3. Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Takashima S, et al. Mol Genet Metab, 2021 Jul. PMID 34016526
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very-long-chain enoyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    trans-2,3-enoyl-CoA reductase b
    Names
    glycoprotein, synaptic 2
    tecr
    NP_958456.1
    XP_021335340.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201299.1 → NP_958456.1  trans-2,3-enoyl-CoA reductase b

      See identical proteins and their annotated locations for NP_958456.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053209
      UniProtKB/TrEMBL
      B2GNT0, F6NM58, Q7T390
      Related
      ENSDARP00000098524.2, ENSDART00000108838.4
      Conserved Domains (2) summary
      cd01801
      Location:6 → 81
      Tsc13_N; Ubiquitin-like domain of Tsc13
      cl21511
      Location:155 → 308
      PEMT; Phospholipid methyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      55752643..55779096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479665.2 → XP_021335340.1  trans-2,3-enoyl-CoA reductase b isoform X1

      UniProtKB/TrEMBL
      A0A8M9QLQ8
      Conserved Domains (1) summary
      PLN02560
      Location:63 → 345
      PLN02560; enoyl-CoA reductase
    Nucleotide Protein Strain
    Heading Accession and Version

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