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    pold1 polymerase (DNA directed), delta 1, catalytic subunit [ Danio rerio (zebrafish) ]

    Gene ID: 556456, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pold1provided by ZNC
    Official Full Name
    polymerase (DNA directed), delta 1, catalytic subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060429-1
    See related
    Ensembl:ENSDARG00000027689 AllianceGenome:ZFIN:ZDB-GENE-060429-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fla; im:7139126; zgc:152688
    Summary
    Predicted to enable 3'-5'-DNA exonuclease activity and DNA-directed DNA polymerase activity. Acts upstream of or within DNA replication. Predicted to be located in nucleus. Predicted to be part of delta DNA polymerase complex. Is expressed in several structures, including brain; immature eye; neural crest; proliferative region; and retina. Orthologous to human POLD1 (DNA polymerase delta 1, catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pold1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (16687830..16719244, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (16538030..16569444, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 17 member 7a Neighboring gene zgc:55558 Neighboring gene glycogen synthase 1 (muscle) Neighboring gene aspartate dehydrogenase domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Neural degeneration mutants in the zebrafish, Danio rerio. Furutani-Seiki M, et al. Development, 1996 Dec. PMID 9007243
    2. Jaw and branchial arch mutants in zebrafish I: branchial arches. Schilling TF, et al. Development, 1996 Dec. PMID 9007253
    3. A ΔRaf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures. He S, et al. J Pathol, 2011 Sep. PMID 21744342
    4. Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. Neuhauss SC, et al. J Neurosci, 1999 Oct 1. PMID 10493760, Free PMC Article
    5. Genes involved in forebrain development in the zebrafish, Danio rerio. Heisenberg CP, et al. Development, 1996 Dec. PMID 9007240

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC152688

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3'-5'-DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication proofreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair, gap-filling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair, DNA gap filling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of delta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase delta catalytic subunit
    Names
    DNA polymerase delta1 catalytic subunit
    flat head
    NP_001034899.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039810.2 → NP_001034899.1  DNA polymerase delta catalytic subunit

      See identical proteins and their annotated locations for NP_001034899.1

      Status: PROVISIONAL

      Source sequence(s)
      AY883095
      UniProtKB/TrEMBL
      Q2KNE0
      Related
      ENSDARP00000055858.4, ENSDART00000055859.5
      Conserved Domains (4) summary
      cd05777
      Location:308 → 537
      DNA_polB_delta_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase delta, a family-B DNA polymerase
      cd05533
      Location:583 → 978
      POLBc_delta; DNA polymerase type-B delta subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. Presently, no direct data is available regarding ...
      PTZ00166
      Location:59 → 1104
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
      pfam14260
      Location:1016 → 1086
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      16687830..16719244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394525.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      322353..342394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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