rbmx RNA binding motif protein X-linked [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rbmxprovided by ZNC
Official Full Name: RNA binding motif protein X-linkedprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-579
See related: Ensembl:ENSDARG00000014244 AllianceGenome:ZFIN:ZDB-GENE-030131-579
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc66e11; hnRNP G; wu:fb37c07; wu:fc66e11
Summary: Predicted to enable chromatin binding activity and nucleic acid binding activity. Predicted to be involved in several processes, including RNA metabolic process; cellular response to interleukin-1; and regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in euchromatin; extracellular exosome; and nucleus. Predicted to be part of catalytic step 2 spliceosome and supraspliceosomal complex. Is expressed in several structures, including brain; digestive system; immature eye; notochord; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in X-linked mental retardation Gustavson type and syndromic X-linked intellectual disability Shashi type. Orthologous to several human genes including RBMX (RNA binding motif protein X-linked). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (31855592..31862721, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (31517459..31522423, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

rbmx is required for normal embryonic development, in particular of the brain, consistent with a role in X-linked mental retardation
Title: RBMX gene is essential for brain development in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

AI415958 (e-PCR)
- UniSTS:206635

fb37c07.x1 (e-PCR)
- UniSTS:190512

fb37c07 (e-PCR)
- UniSTS:187125

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables snRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane protein ectodomain proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	ISS Inferred from Sequence or Structural Similarity more info
located_in euchromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info
part_of supraspliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: RNA-binding motif protein, X chromosome

Names: heterogeneous nuclear ribonucleoprotein G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212598.1 → NP_997763.1 RNA-binding motif protein, X chromosome

See identical proteins and their annotated locations for NP_997763.1

Status: PROVISIONAL

Source sequence(s)

BC049509

UniProtKB/Swiss-Prot

Q6TLG7, Q7ZWA3

UniProtKB/TrEMBL

A0A8M9QP18

Related

ENSDARP00000111610.3, ENSDART00000128730.4

Conserved Domains (2) summary

cd12382
Location:7 → 86

RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

cl25887
Location:10 → 204

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

31855592..31862721 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017358984.3 → XP_017214473.1 RNA-binding motif protein, X chromosome isoform X1

UniProtKB/TrEMBL

A0A8M6Z2K5

Conserved Domains (3) summary

cd12382
Location:7 → 86

RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

pfam07415
Location:134 → 239

Herpes_LMP2; Gammaherpesvirus latent membrane protein (LMP2) protein

pfam08081
Location:153 → 194

RBM1CTR; RBM1CTR (NUC064) family