zbtb8a zinc finger and BTB domain containing 8A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: zbtb8aprovided by ZNC
Official Full Name: zinc finger and BTB domain containing 8Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060421-5153
See related: Ensembl:ENSDARG00000059226 AllianceGenome:ZFIN:ZDB-GENE-060421-5153
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:136874
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in epidermal cell. Orthologous to human ZBTB8A (zinc finger and BTB domain containing 8A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (24869493..24879003, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (24850995..24860602, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 8A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040250.2 → NP_001035340.2 zinc finger and BTB domain-containing protein 8A

Status: VALIDATED

Source sequence(s)

CR391986

UniProtKB/TrEMBL

A0A8M1N8I9, F1RE12

Related

ENSDARP00000112298.2, ENSDART00000123147.3

Conserved Domains (5) summary

smart00225
Location:55 → 152

BTB; Broad-Complex, Tramtrack and Bric a brac

COG5048
Location:304 → 357

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:306 → 326

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:44 → 149

BTB; BTB/POZ domain

pfam13465
Location:318 → 343

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

24869493..24879003 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009293047.4 → XP_009291322.1 zinc finger and BTB domain-containing protein 8A isoform X1

See identical proteins and their annotated locations for XP_009291322.1

UniProtKB/TrEMBL

Q1RLS8

Conserved Domains (5) summary

smart00225
Location:24 → 121

BTB; Broad-Complex, Tramtrack and Bric a brac

COG5048
Location:273 → 326

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:275 → 295

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:13 → 118

BTB; BTB/POZ domain

pfam13465
Location:287 → 312

zf-H2C2_2; Zinc-finger double domain