hoga1 4-hydroxy-2-oxoglutarate aldolase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hoga1provided by ZNC
Official Full Name: 4-hydroxy-2-oxoglutarate aldolase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2242
See related: Ensembl:ENSDARG00000018944 AllianceGenome:ZFIN:ZDB-GENE-040426-2242
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77082
Summary: Predicted to enable (R,S)-4-hydroxy-2-oxoglutarate aldolase activity and N-acetylneuraminate lyase activity. Predicted to be involved in N-acetylneuraminate catabolic process and glyoxylate catabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 3. Orthologous to human HOGA1 (4-hydroxy-2-oxoglutarate aldolase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (34710473..34733026)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (34735566..34758029)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables (4S)-4-hydroxy-2-oxoglutarate aldolase activity	IEA Inferred from Electronic Annotation more info
enables (R,S)-4-hydroxy-2-oxoglutarate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables (R,S)-4-hydroxy-2-oxoglutarate aldolase activity	IEA Inferred from Electronic Annotation more info
enables (R,S)-4-hydroxy-2-oxoglutarate aldolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glyoxylate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyoxylate catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Names: DHDPS-like protein; dihydrodipicolinate synthase-like, mitochondrial; probable 2-keto-4-hydroxyglutarate aldolase; probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; probable KHG-aldolase

NP_998035.1

EC 4.1.3.16

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212870.1 → NP_998035.1 4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor

See identical proteins and their annotated locations for NP_998035.1

Status: PROVISIONAL

Source sequence(s)

BC066708

UniProtKB/Swiss-Prot

Q6NY77

Related

ENSDARP00000021126.6, ENSDART00000025820.9

Conserved Domains (1) summary

cd00408
Location:35 → 315

DHDPS-like; Dihydrodipicolinate synthase family