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    sf3a3 splicing factor 3a, subunit 3 [ Danio rerio (zebrafish) ]

    Gene ID: 446168, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sf3a3provided by ZNC
    Official Full Name
    splicing factor 3a, subunit 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040908-1
    See related
    Ensembl:ENSDARG00000100114 AllianceGenome:ZFIN:ZDB-GENE-040908-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    SAP61; SF3a60; wu:fi15a06; wu:fj94f01; zgc:110227
    Summary
    Predicted to enable RNA binding activity. Acts upstream of or within hematopoietic stem cell differentiation. Predicted to be located in nucleus. Predicted to be part of spliceosomal complex. Orthologous to human SF3A3 (splicing factor 3a subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sf3a3 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (17292667..17304994, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (17388305..17400632, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438143 Neighboring gene mannosidase endo-alpha like Neighboring gene ubiquitin-conjugating enzyme E2E 1 Neighboring gene NFKB inhibitor interacting Ras-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Burns CE, et al. Blood, 2009 Jun 4. PMID 19332767, Free PMC Article
    2. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Trinh le A, et al. Genes Dev, 2011 Nov 1. PMID 22056673, Free PMC Article
    3. New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. Tseng LC, et al. PLoS One, 2014. PMID 24714733, Free PMC Article
    4. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110227

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor 3A subunit 3
    Names
    spliceosome associated protein 61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004289.1 → NP_001004289.1  splicing factor 3A subunit 3

      See identical proteins and their annotated locations for NP_001004289.1

      Status: PROVISIONAL

      Source sequence(s)
      AY648757
      UniProtKB/TrEMBL
      Q6DRK2
      Related
      ENSDARP00000140243.1, ENSDART00000160433.3
      Conserved Domains (5) summary
      COG5188
      Location:2 → 501
      PRP9; Splicing factor 3a, subunit 3 [RNA processing and modification]
      pfam11931
      Location:323 → 498
      DUF3449; Domain of unknown function (DUF3449)
      pfam12108
      Location:74 → 100
      SF3a60_bindingd; Splicing factor SF3a60 binding domain
      pfam13297
      Location:244 → 303
      Telomere_Sde2_2; Telomere stability C-terminal
      pfam16837
      Location:129 → 204
      SF3A3; Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      17292667..17304994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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