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    mak male germ cell-associated kinase [ Danio rerio (zebrafish) ]

    Gene ID: 335339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    makprovided by ZNC
    Official Full Name
    male germ cell-associated kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7279
    See related
    Ensembl:ENSDARG00000059287 AllianceGenome:ZFIN:ZDB-GENE-030131-7279
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Ick; fj04c02; zgc:56603; wu:fj04c02
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within motile cilium assembly. Predicted to be active in cilium; cytoplasm; and nucleus. Is expressed in Kupffer's vesicle; retina; and retinal photoreceptor layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa 62. Orthologous to human MAK (male germ cell associated kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mak in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (8740477..8777570, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (8601725..8637202, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member B3 Neighboring gene transcription factor AP-2 alpha Neighboring gene transmembrane protein 14Ca Neighboring gene uncharacterized LOC110438349 Neighboring gene glial cells missing transcription factor 2 Neighboring gene synaptonemal complex protein 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Male germ cell-associated kinase is required for axoneme formation during ciliogenesis in zebrafish photoreceptors. Chiang HJ, et al. Dis Model Mech, 2024 Jul 1. PMID 38813692, Free PMC Article
    2. Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa. Tucker BA, et al. Gene Ther, 2022 May. PMID 34518651, Free PMC Article
    3. The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. Lv Y, et al. J Biol Chem, 2024 Mar. PMID 38382674, Free PMC Article
    4. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
    5. Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Shim H, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27903883, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Male germ cell-associated kinase is required for axoneme formation during ciliogenesis in zebrafish photoreceptors.
      Title: Male germ cell-associated kinase is required for axoneme formation during ciliogenesis in zebrafish photoreceptors.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase MAK
    Names
    intestinal cell kinase
    NP_956240.1
    XP_005162620.1
    XP_005162621.1
    XP_009295564.1
    XP_009295566.1
    XP_021325788.1
    XP_068073134.1
    XP_068073135.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199946.1 → NP_956240.1  serine/threonine-protein kinase MAK

      See identical proteins and their annotated locations for NP_956240.1

      Status: PROVISIONAL

      Source sequence(s)
      BC052126
      UniProtKB/TrEMBL
      Q7ZTX0
      Related
      ENSDARP00000076797.4, ENSDART00000082362.6
      Conserved Domains (2) summary
      smart00220
      Location:4 → 285
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07830
      Location:4 → 285
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      8740477..8777570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470113.2 → XP_021325788.1  serine/threonine-protein kinase MAK isoform X5

      UniProtKB/TrEMBL
      A0A8M9PFV2
      Conserved Domains (1) summary
      cd07830
      Location:4 → 285
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    2. XM_005162564.5 → XP_005162621.1  serine/threonine-protein kinase MAK isoform X3

      UniProtKB/TrEMBL
      A0A8M2B9R2
      Conserved Domains (2) summary
      smart00220
      Location:4 → 285
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07830
      Location:4 → 285
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    3. XM_009297291.4 → XP_009295566.1  serine/threonine-protein kinase MAK isoform X4

      UniProtKB/TrEMBL
      A0A8M3ANF8
      Conserved Domains (2) summary
      smart00220
      Location:4 → 284
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07830
      Location:4 → 284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    4. XM_005162563.5 → XP_005162620.1  serine/threonine-protein kinase MAK isoform X2

      UniProtKB/TrEMBL
      A0A286Y937, A0A8M2B9F1
      Related
      ENSDARP00000143675.1, ENSDART00000177400.2
      Conserved Domains (2) summary
      smart00220
      Location:4 → 284
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07830
      Location:4 → 284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    5. XM_009297289.4 → XP_009295564.1  serine/threonine-protein kinase MAK isoform X1

      UniProtKB/TrEMBL
      A0A8M3AVX2, F1QUT2
      Conserved Domains (2) summary
      smart00220
      Location:4 → 285
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07830
      Location:4 → 285
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    6. XM_068217034.1 → XP_068073135.1  serine/threonine-protein kinase MAK isoform X4

      UniProtKB/TrEMBL
      A0A8M3ANF8

    7. XM_068217033.1 → XP_068073134.1  serine/threonine-protein kinase MAK isoform X2

      UniProtKB/TrEMBL
      A0A286Y937, A0A8M2B9F1
    Nucleotide Protein Strain
    Heading Accession and Version

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