ddx18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ddx18provided by ZNC
Official Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 18provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9685
See related: Ensembl:ENSDARG00000030789 AllianceGenome:ZFIN:ZDB-GENE-030131-9685
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb155; fa19d11; sb:cb155; wu:fa19d11
Summary: Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Acts upstream of or within myeloid cell differentiation. Predicted to be active in nucleolus. Is expressed in several structures, including alar plate midbrain region; digestive system; intermediate cell mass of mesoderm; nervous system; and trunk vasculature. Orthologous to human DDX18 (DEAD-box helicase 18). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (38315067..38352207)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (38505272..38542412)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In a zebrafish mutagenesis we identified an insertional allele hi1727, which disrupts the gene encoding RNA helicase dead-box 18 (Ddx18).
Title: Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML.

Submit: New GeneRIF Correction

General gene information

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Markers

fb55a09.y1 (e-PCR)
- UniSTS:190722

aa605782 (e-PCR)
- UniSTS:186898

fa19d11.s1 (e-PCR)
- UniSTS:202446

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DDX18

NP_001003411.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003411.1 → NP_001003411.1 ATP-dependent RNA helicase DDX18

See identical proteins and their annotated locations for NP_001003411.1

Status: PROVISIONAL

Source sequence(s)

AY648748

UniProtKB/TrEMBL

Q6DRL1

Related

ENSDARP00000048752.6, ENSDART00000048753.7

Conserved Domains (4) summary

COG0513
Location:160 → 646

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd00079
Location:382 → 511

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:161 → 368

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam13959
Location:543 → 601

DUF4217; Domain of unknown function (DUF4217)