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    aldoca aldolase C, fructose-bisphosphate, a [ Danio rerio (zebrafish) ]

    Gene ID: 792692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aldocaprovided by ZNC
    Official Full Name
    aldolase C, fructose-bisphosphate, aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050706-128
    See related
    Ensembl:ENSDARG00000057661 AllianceGenome:ZFIN:ZDB-GENE-050706-128
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    aldocl; wu:fj56h04; zgc:112357
    Summary
    Predicted to enable fructose-bisphosphate aldolase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process and glycolytic process. Predicted to be active in cytosol. Is expressed in brain. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system. Orthologous to human ALDOC (aldolase, fructose-bisphosphate C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See aldoca in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (16079586..16121460, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (16143564..16162134, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene dynein, light chain, LC8-type 2a Neighboring gene serine and arginine rich splicing factor 1a Neighboring gene si:ch211-259g3.4 Neighboring gene glyoxalase domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Establishment of Gal4 transgenic zebrafish lines for analysis of development of cerebellar neural circuitry. Takeuchi M, et al. Dev Biol, 2015 Jan 1. PMID 25300581
    2. Functionally distinct Purkinje cell types show temporal precision in encoding locomotion. Chang W, et al. Proc Natl Acad Sci U S A, 2020 Jul 21. PMID 32632015, Free PMC Article
    3. Involvement of Cerebellar Neural Circuits in Active Avoidance Conditioning in Zebrafish. Koyama W, et al. eNeuro, 2021 May-Jun. PMID 33952613, Free PMC Article
    4. Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours. Knogler LD, et al. Elife, 2019 Jan 25. PMID 30681408, Free PMC Article
    5. Atypical protein kinase C regulates primary dendrite specification of cerebellar Purkinje cells by localizing Golgi apparatus. Tanabe K, et al. J Neurosci, 2010 Dec 15. PMID 21159968, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112357

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables fructose-bisphosphate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose-bisphosphate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fructose-bisphosphate aldolase C-A
    Names
    aldolase c, fructose-bisphosphate, like
    zebrin II
    NP_001025123.1
    XP_068069708.1
    XP_068069709.1
    XP_068069710.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029952.1 → NP_001025123.1  fructose-bisphosphate aldolase C-A

      See identical proteins and their annotated locations for NP_001025123.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098624
      UniProtKB/Swiss-Prot
      Q4KMC8
      Related
      ENSDARP00000074827.5, ENSDART00000080377.7
      Conserved Domains (1) summary
      pfam00274
      Location:15 → 364
      Glycolytic; Fructose-bisphosphate aldolase class-I

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      16079586..16121460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213608.1 → XP_068069709.1  fructose-bisphosphate aldolase C-A isoform X2

    2. XM_068213607.1 → XP_068069708.1  fructose-bisphosphate aldolase C-A isoform X1

    3. XM_068213609.1 → XP_068069710.1  fructose-bisphosphate aldolase C-A isoform X3

      UniProtKB/TrEMBL
      A0A8M3AIE2, F1QC70

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394942.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      87715..103731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KMC8.1 GenPept UniProtKB/Swiss-Prot:Q4KMC8

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