b3gnt5a UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: b3gnt5aprovided by ZNC
Official Full Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8470
See related: Ensembl:ENSDARG00000018971 AllianceGenome:ZFIN:ZDB-GENE-030131-8470
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Lc3; b3gnt5; fb12f12; wu:fb12f12; wu:fe50g08
Summary: Predicted to enable N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to act upstream of or within lipid metabolic process and protein glycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane. Is expressed in solid lens vesicle. Orthologous to human B3GNT5 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (10541258..10550309)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (10557566..10566617)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Together, these results provide new evidence that the Rubicon-dependent Lc3-associated phagocytosis process is an important defense mechanism against Salmonella typhimurium.
Title: Rubicon-Dependent Lc3 Recruitment to Salmonella-Containing Phagosomes Is a Host Defense Mechanism Triggered Independently From Major Bacterial Virulence Factors.
Hedgehog signaling is required for the Lc3 synthase expression in embryonic lens
Title: Expression of zebrafish Lc3 synthase gene in embryonic lens requires hedgehog signaling.

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General gene information

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Markers

fe50g08.x1 (e-PCR)
- UniSTS:204410

fb12f12.x1 (e-PCR)
- UniSTS:202875

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A

Names: BGnT-5A; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5A; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5; beta-1,3-Gn-T5A; beta-1,3-N-acetylglucosaminyltransferase 5A; beta3Gn-T5A; lactotriaosylceramide synthase A; lc(3)Cer synthase A; lc3 synthase A

NP_942577.1

EC 2.4.1.206

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.