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    naa35 N-alpha-acetyltransferase 35, NatC auxiliary subunit [ Danio rerio (zebrafish) ]

    Gene ID: 321587, updated on 9-Dec-2024

    Summary

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    Official Symbol
    naa35provided by ZNC
    Official Full Name
    N-alpha-acetyltransferase 35, NatC auxiliary subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-306
    See related
    Ensembl:ENSDARG00000012378 AllianceGenome:ZFIN:ZDB-GENE-030131-306
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mak10; zgc:64157; wu:fb21g10
    Summary
    Acts upstream of or within several processes, including blood vessel morphogenesis; regulation of TOR signaling; and somitogenesis. Predicted to be located in cytoplasm. Predicted to be part of NatC complex. Is expressed in blood vasculature; epidermis; and head. Orthologous to human NAA35 (N-alpha-acetyltransferase 35, NatC auxiliary subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See naa35 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (49936585..49969184)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (49947816..49980415)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene neurotrophic tyrosine kinase, receptor, type 2a Neighboring gene ATP/GTP binding carboxypeptidase 1 Neighboring gene glutamine--fructose-6-phosphate transaminase 1 Neighboring gene ANTXR cell adhesion molecule 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. Wenzlau JM, et al. Circ Res, 2006 Mar 31. PMID 16484612
    2. A Genetic Model to Study Increased Hexosamine Biosynthetic Flux. Hugo SE, et al. Endocrinology, 2017 Aug 1. PMID 28582574, Free PMC Article
    3. Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish. Huo X, et al. Sci Rep, 2019 Feb 6. PMID 30728369, Free PMC Article
    4. Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish. Yang CT, et al. PLoS Genet, 2007 Jun. PMID 17542649, Free PMC Article
    5. Heat-induced masculinization in domesticated zebrafish is family-specific and yields a set of different gonadal transcriptomes. Ribas L, et al. Proc Natl Acad Sci U S A, 2017 Feb 7. PMID 28115725, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within N-terminal peptidyl-methionine acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NatC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of NatC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 35, NatC auxiliary subunit
    Names
    EGAP NAT
    MAK10 homolog, amino-acid N-acetyltransferase subunit
    embryonic growth-associated protein
    protein MAK10 homolog
    zEGAP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199550.1 → NP_955844.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit

      See identical proteins and their annotated locations for NP_955844.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053286
      UniProtKB/Swiss-Prot
      Q7T322
      Related
      ENSDARP00000089478.3, ENSDART00000098707.6
      Conserved Domains (1) summary
      pfam04112
      Location:45 → 180
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      49936585..49969184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T322.1 GenPept UniProtKB/Swiss-Prot:Q7T322

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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