aagab alpha and gamma adaptin binding protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aagabprovided by ZNC
Official Full Name: alpha and gamma adaptin binding proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-120
See related: Ensembl:ENSDARG00000041170 AllianceGenome:ZFIN:ZDB-GENE-040718-120
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92663; wu:fa20c02
Summary: Predicted to enable GTP binding activity and GTPase activity. Human ortholog(s) of this gene implicated in punctate palmoplantar keratoderma type I. Orthologous to human AAGAB (alpha and gamma adaptin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (19812614..19819785, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (19823548..19830719, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aagab is required for zebrafish larval development by regulating neural activity.
Title: Aagab is required for zebrafish larval development by regulating neural activity.

Submit: New GeneRIF Correction

General gene information

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Markers

fc81b02.y1 (e-PCR)
- UniSTS:194584

fa20c02.s1 (e-PCR)
- UniSTS:202461

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha- and gamma-adaptin-binding protein p34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002423.1 → NP_001002423.1 alpha- and gamma-adaptin-binding protein p34

See identical proteins and their annotated locations for NP_001002423.1

Status: PROVISIONAL

Source sequence(s)

BC076147

UniProtKB/TrEMBL

Q6DH35

Related

ENSDARP00000060343.3, ENSDART00000060344.4

Conserved Domains (2) summary

pfam10199
Location:164 → 300

Adaptin_binding; Alpha and gamma adaptin binding protein p34

cl21455
Location:82 → 149

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases