pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pik3cgprovided by ZNC
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gammaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2532
See related: Ensembl:ENSDARG00000017757 AllianceGenome:ZFIN:ZDB-GENE-040426-2532
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77033; wu:fb15d07
Summary: Predicted to enable 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity. Acts upstream of or within neutrophil chemotaxis. Human ortholog(s) of this gene implicated in autistic disorder; primary immunodeficiency disease; and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (3343173..3355659, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (3329846..3340263, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Names: phosphoinositide-3-kinase, catalytic, gamma polypeptide

NP_998471.1

EC 2.7.1.137

XP_021330656.1

EC 2.7.1.137

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213306.1 → NP_998471.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

See identical proteins and their annotated locations for NP_998471.1

Status: PROVISIONAL

Source sequence(s)

BC068983

UniProtKB/TrEMBL

A0A8M9PH51, Q6NTI2, Q6PFT5

Related

ENSDARP00000002818.6, ENSDART00000009076.8

Conserved Domains (4) summary

cd08399
Location:351 → 522

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

cd00872
Location:544 → 720

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:724 → 1090

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

pfam00794
Location:206 → 312

PI3K_rbd; PI3-kinase family, ras-binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

3343173..3355659 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474981.2 → XP_021330656.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

UniProtKB/TrEMBL

A0A8M9PH51, A0A8M9Q5U7

Conserved Domains (4) summary

cd08399
Location:366 → 537

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

cd00872
Location:559 → 735

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:739 → 1105

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

pfam00794
Location:221 → 327

PI3K_rbd; PI3-kinase family, ras-binding domain