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    dub duboraya [ Danio rerio (zebrafish) ]

    Gene ID: 566846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dubprovided by ZNC
    Official Full Name
    duborayaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060825-81
    See related
    Ensembl:ENSDARG00000059774 AllianceGenome:ZFIN:ZDB-GENE-060825-81
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153303
    Summary
    Acts upstream of or within cilium assembly and heart development. Predicted to be active in muscle cell projection membrane and ruffle membrane. Is expressed in blood island; cardiovascular system; pronephric duct; somite; and tail bud. Orthologous to human RCSD1 (RCSD domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dub in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (22917981..22951627, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (22881376..22915021, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene ALG8 alpha-1,3-glucosyltransferase Neighboring gene guanylate cyclase activator 1d Neighboring gene cysteinyl leukotriene receptor 2a Neighboring gene retinoblastoma 1 Neighboring gene uncharacterized LOC137488813

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. Oishi I, et al. Nat Genet, 2006 Nov. PMID 17013396
    2. Heterogeneous pdgfrb+ cells regulate coronary vessel development and revascularization during heart regeneration. Kapuria S, et al. Development, 2022 Feb 15. PMID 35088848, Free PMC Article
    3. Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer. Yee NS, et al. Dis Model Mech, 2011 Mar. PMID 21183474, Free PMC Article
    4. From zebrafish heart jogging genes to mouse and human orthologs: using Gene Ontology to investigate mammalian heart development. Khodiyar VK, et al. F1000Res, 2013. PMID 24627794, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of a zebrafish gene, termed duboraya (dub), that is essential for ciliogenesis and left-right patterning.
      Title: Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153303, MGC191431

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart jogging IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macrophage apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within non-canonical Wnt signaling pathway involved in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    duboraya

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045422.1 → NP_001038887.1  duboraya

      See identical proteins and their annotated locations for NP_001038887.1

      Status: PROVISIONAL

      Source sequence(s)
      BC122224
      UniProtKB/TrEMBL
      Q0P484
      Related
      ENSDARP00000151739.1, ENSDART00000180129.1
      Conserved Domains (1) summary
      pfam15255
      Location:71 → 178
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      22917981..22951627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161193.5 → XP_005161250.1  duboraya isoform X1

      UniProtKB/TrEMBL
      A0A8M2B856
      Conserved Domains (1) summary
      pfam15255
      Location:42 → 149
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
    Nucleotide Protein Strain
    Heading Accession and Version

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