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    pelo pelota mRNA surveillance and ribosome rescue factor [ Danio rerio (zebrafish) ]

    Gene ID: 394111, updated on 2-Nov-2024

    Summary

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    Official Symbol
    peloprovided by ZNC
    Official Full Name
    pelota mRNA surveillance and ribosome rescue factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1074
    See related
    Ensembl:ENSDARG00000055477 AllianceGenome:ZFIN:ZDB-GENE-040426-1074
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ITGA1; zgc:56550; wu:fa12c12; wu:fb97f07
    Summary
    Predicted to enable ribosome binding activity. Predicted to be involved in nonfunctional rRNA decay; nuclear-transcribed mRNA catabolic process, no-go decay; and rescue of stalled ribosome. Predicted to act upstream of or within RNA surveillance; cell division; and nuclear-transcribed mRNA catabolic process, non-stop decay. Predicted to be part of Dom34-Hbs1 complex. Predicted to be active in cytoplasm. Orthologous to human PELO (pelota mRNA surveillance and ribosome rescue factor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pelo in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (13189213..13205562, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (13150910..13167259, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene calymmin Neighboring gene CX chemokine ligand 34c Neighboring gene progestin and adipoQ receptor family member IVb Neighboring gene protein phosphatase 1, catalytic subunit, alpha isozyme b Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56550

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA surveillance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nonfunctional rRNA decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, no-go decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, no-go decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, no-go decay ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, non-stop decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rescue of stalled ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosome disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Dom34-Hbs1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein pelota homolog
    Names
    pelota homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201136.1 → NP_957430.1  protein pelota homolog

      See identical proteins and their annotated locations for NP_957430.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049484
      UniProtKB/Swiss-Prot
      Q7ZWC4
      Related
      ENSDARP00000072295.4, ENSDART00000077829.6
      Conserved Domains (4) summary
      COG1537
      Location:1 → 370
      PelA; Stalled ribosome rescue protein Dom34, pelota family [Translation, ribosomal structure and biogenesis]
      pfam03463
      Location:1 → 128
      eRF1_1; eRF1 domain 1
      pfam03464
      Location:136 → 268
      eRF1_2; eRF1 domain 2
      pfam03465
      Location:271 → 370
      eRF1_3; eRF1 domain 3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      13189213..13205562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZWC4.1 GenPept UniProtKB/Swiss-Prot:Q7ZWC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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