tbx16l T-box transcription factor 16, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tbx16lprovided by ZNC
Official Full Name: T-box transcription factor 16, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-171
See related: Ensembl:ENSDARG00000006939 AllianceGenome:ZFIN:ZDB-GENE-980526-171
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tbx6; cb123; tbx6l; z.TBX6; ZF-TBX6; sb:cb123; etID309793.5
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within paraxial mesoderm formation and somite development. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in embryonic structure; hematopoietic system; mesoderm; and post-vent region. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 5. Orthologous to human TBX6 (T-box transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (42280576..42302297)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (41680025..41702147)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis.
Title: Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis.
Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish.
Title: Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish.
Results present a model in which overlapping Wnt and Bmp signals in the ventrolateral region activate the expression of tbx6 and other posterior mesodermal genes, leading to the formation of posterior structures.
Title: Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Z22309 (e-PCR)
- UniSTS:204661

tbx6 (e-PCR), detects polymorphism
- UniSTS:187038

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within paraxial mesoderm formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somite development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: T-box transcription factor TBX6L

Names: T-box 16, like; T-box 6, like; T-box protein 6; T-box protein 6L; T-box transcription factor TBX6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131052.2 → NP_571127.2 T-box transcription factor TBX6L

Status: VALIDATED

Source sequence(s)

BX548073

UniProtKB/Swiss-Prot

P79742

UniProtKB/TrEMBL

A0A8M1PB76

Related

ENSDARP00000113982.1, ENSDART00000142855.2

Conserved Domains (1) summary

cd00182
Location:33 → 221

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

42280576..42302297

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017356037.3 → XP_017211526.1 T-box transcription factor TBX6L isoform X2

UniProtKB/TrEMBL

A0A8M6Z0I2
XM_017356035.3 → XP_017211524.1 T-box transcription factor TBX6L isoform X1

UniProtKB/Swiss-Prot

P79742

UniProtKB/TrEMBL

A0A8M6YZ11