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    stag2a STAG2 cohesin complex component a [ Danio rerio (zebrafish) ]

    Gene ID: 567168, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stag2aprovided by ZNC
    Official Full Name
    STAG2 cohesin complex component aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3432
    See related
    Ensembl:ENSDARG00000011783 AllianceGenome:ZFIN:ZDB-GENE-030131-3432
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc39a01; wu:fc39a01; si:dkeyp-20g2.6
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in sister chromatid cohesion. Predicted to act upstream of or within chromosome segregation. Predicted to be located in chromatin. Predicted to be part of cohesin complex. Predicted to be active in nucleus. Is expressed in head and trunk. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked and Mullegama-Klein-Martinez syndrome. Orthologous to human STAG2 (STAG2 cohesin complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stag2a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (23488055..23517803, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (22984255..23014010, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene glutamate receptor, ionotropic, AMPA 3a Neighboring gene si:dkeyp-20g2.1 Neighboring gene acyl-CoA synthetase long chain family member 4b Neighboring gene CWC15 spliceosome associated protein homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Ketharnathan S, et al. Front Cell Dev Biol, 2020. PMID 33365313, Free PMC Article
    2. Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Avagyan S, et al. Science, 2021 Nov 5. PMID 34735227
    3. New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Maugars G, et al. Front Endocrinol (Lausanne), 2020. PMID 33071966, Free PMC Article
    4. High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis. Thomas HR, et al. PLoS One, 2014. PMID 25503746, Free PMC Article
    5. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cohesin subunit SA-2a
    Names
    stromal antigen 2
    stromal antigen 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100028.1 → NP_001093498.1  cohesin subunit SA-2a

      Status: PROVISIONAL

      Source sequence(s)
      CR926467
      UniProtKB/TrEMBL
      A0A8M1NE13, A5WV17
      Related
      ENSDARP00000112624.1, ENSDART00000137655.2
      Conserved Domains (1) summary
      pfam08514
      Location:144 → 252
      STAG; STAG domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      23488055..23517803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301356.4 → XP_009299631.1  cohesin subunit SA-2a isoform X2

      UniProtKB/TrEMBL
      A0A8M3B9I6
      Conserved Domains (1) summary
      pfam08514
      Location:143 → 251
      STAG; STAG domain

    2. XM_017356146.3 → XP_017211635.1  cohesin subunit SA-2a isoform X1

      UniProtKB/TrEMBL
      A0A8M1NE13, A5WV17
      Conserved Domains (1) summary
      pfam08514
      Location:144 → 252
      STAG; STAG domain
    Nucleotide Protein Strain
    Heading Accession and Version

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